Interaction between tumor cells and immune cells in the tumor microenvironment is
important in cancer development. Immune cells interact with the tumor cells to shape this …

Diverse immune cells in the tumor microenvironment form a complex ecosystem, but our
knowledge of their heterogeneity and dynamics within hepatocellular carcinoma (HCC) still …

The general relevance of the immune system for cancer development and therapy is
increasingly recognized. However and although the immune contexture of most human …

The clinical relevance of immune landscape intratumoural heterogeneity (immune-ITH) and
its role in tumour evolution remain largely unexplored. Here, we uncover significant spatial …

The recent development of immunotherapy as a cancer treatment has proved effective over
recent years, but the precise dynamics between the tumor microenvironment (TME) …

Background The tumor microenvironment can be classified into immunologically active"
inflamed" tumors and inactive" non-inflamed" tumors based on the infiltration of cytotoxic …

Background & aims Agents that induce an immune response against tumors by altering T-
cell regulation have increased survival times of patients with advanced-stage tumors, such …

Hepatocellular carcinoma (HCC) represents a paradigm of the relation between tumor
microenvironment (TME) and tumor development. Here, we generate a single-cell atlas of …

Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of
immunotherapies and the prediction of their clinical responses in cancers. Here, we perform …

Background and aims Chronic inflammation induced by chronic hepatitis B virus (HBV)
infection increases the risk of hepatocellular carcinoma (HCC). However, little is known …