High-resolution map of the Fc functions mediated by COVID-19-neutralizing antibodies

I Paciello, G Maccari, E Pantano… - Proceedings of the …, 2024 - National Acad Sciences
A growing body of evidence shows that fragment crystallizable (Fc)-dependent antibody
effector functions play an important role in protection from severe acute respiratory …

[HTML][HTML] Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection

A Zhang, HD Stacey, MR D'Agostino, Y Tugg… - Nature Reviews …, 2023 - nature.com
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …

[PDF][PDF] Decay of Fc-dependent antibody functions after mild to moderate COVID-19

WS Lee, KJ Selva, SK Davis, BD Wines, A Reynaldi… - Cell Reports …, 2021 - cell.com
The capacity of antibodies to engage with immune cells via the Fc region is important in
preventing and controlling many infectious diseases. The evolution of such antibodies …

[PDF][PDF] A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

G Beaudoin-Bussières, Y Chen, I Ullah, J Prévost… - Cell reports, 2022 - cell.com
Emerging evidence indicates that both neutralizing and Fc-mediated effector functions of
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …

[HTML][HTML] Fc-independent protection from SARS-CoV-2 infection by recombinant human monoclonal antibodies

T Noy-Porat, A Edri, R Alcalay, E Makdasi, D Gur… - Antibodies, 2021 - mdpi.com
The use of passively-administered neutralizing antibodies is a promising approach for the
prevention and treatment of SARS-CoV-2 infection. Antibody-mediated protection may …

[HTML][HTML] Evaluation of strategies to modify Anti-SARS-CoV-2 monoclonal antibodies for optimal functionality as therapeutics

RV House, TA Broge, TJ Suscovich, DM Snow… - PloS one, 2022 - journals.plos.org
The current global COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has resulted in a public health crisis with more than 168 million …

[HTML][HTML] Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

CN Pierre, LE Adams, K Anasti, D Goodman… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Antibodies perform both neutralizing and non-neutralizing effector functions that protect
against certain pathogen-induced diseases. A human antibody directed at the SARS-CoV-2 …

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

D Li, RJ Edwards, K Manne, DR Martinez, A Schäfer… - BioRxiv, 2021 - biorxiv.org
Summary SARS-CoV-2 neutralizing antibodies (NAbs) protect against COVID-19, making
them a focus of vaccine design. A safety concern regarding SARS-CoV-2 antibodies is …

[PDF][PDF] The antigenic anatomy of SARS-CoV-2 receptor binding domain

W Dejnirattisai, D Zhou, HM Ginn, HME Duyvesteyn… - Cell, 2021 - cell.com
Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency
use as therapeutics. Here, we identify 377 human monoclonal antibodies (mAbs) …

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2

H Xiong, H Sun, S Wang, L Yuan… - Proceedings of the …, 2022 - National Acad Sciences
Antibody therapeutics for the treatment of COVID-19 have been highly successful. However,
the recent emergence of the Omicron variant has posed a challenge, as it evades detection …