Heart disease is a significant burden on global health care systems and is a leading cause
of death each year. To improve our understanding of heart disease, high quality disease …

The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture
experiments by allowing a better mimicry of human physiology and pathophysiology that has …

Cardiovascular disease is a major cause of mortality worldwide, and current preclinical
models including traditional animal models and 2D cell culture models have limitations in …

The emergence of human induced pluripotent stem cells (hiPSCs) and efficient
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …

The lack of biomimetic in vitro models of the human heart has posed a critical barrier to
progress in the field of modeling cardiac disease. Human engineered cardiac tissues …

Human heart (patho) physiology is now widely studied using human pluripotent stem cells,
but the immaturity of derivative cardiomyocytes has largely limited disease modeling to …

Cardiovascular organ‐on‐a‐chip (OoC) devices are composed of engineered or native
functional tissues that are cultured under controlled microenvironments inside microchips …

Heart disease is one of the major life-threatening diseases with high mortality and incidence
worldwide. Several model systems, such as primary cells and animals, have been used to …

Cardiac diseases are the leading cause of deaths worldwide; however, to date, there has
been limited progress in the development of therapeutic options for these conditions. Animal …

Heart disease is the leading cause of death worldwide and imposes a significant burden on
healthcare systems globally. A major hurdle to the development of more effective …