Advances in understanding the physiologic functions of the tumor necrosis factor
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …

Tumor necrosis factor (TNF)-related cytokines function as key communication systems
between cells of the immune system and mediate inflammation and tissue destruction …

Abstract The TNF Superfamily member LIGHT (TNFSF14) has recently emerged as a
potential target for therapeutic interventions aiming to halt tissue fibrosis. In this perspective …

Over 1.5 million individuals in the United States are afflicted with inflammatory bowel
disease (IBD). While the progression of IBD is multifactorial, chronic, unresolved …

Tertiary lymphoid structures (TLSs) in tumor tissues facilitate immune cell trafficking and
cytotoxicity, which benefits survival and favorable responses in immune therapy. Here, we …

Background & Aims The pathogenesis of inflammatory bowel disease (IBD) is associated
with a dysregulated mucosal immune response. Expression of the tumor necrosis factor …

Cytokines mediate key communication pathways essential for regulation of immune
responses. Full activation of antigen‐responding lymphocytes requires cooperating signals …

Lymphotoxins (LTα and LTβ), LIGHT [homologous to LT, inducible expression, competes
with herpes simplex virus (HSV) glycoprotein D for HSV entry mediator (HVEM), a receptor …

Costimulatory molecules on antigen-presenting cells (APCs) play an important role in T cell
activation and expansion. However, little is known about the surface molecules involved in …

The delicate balance between the proliferation and elimination of antigenactivated
lymphocytes achieves homeostasis in peripheral lymphoid tissues. The TNF-related …