Aquatic Peptide: The Potential Anti-Cancer and Anti-Microbial Activity of GE18 Derived from Pathogenic Fungus Aphanomyces invadans

M Velayutham, PS Priya, P Sarkar, R Murugan… - Molecules, 2023 - mdpi.com
Small molecules as well as peptide-based therapeutic approaches have attracted global
interest due to their lower or no toxicity in nature, and their potential in addressing several …

Anti-Cancer and Anti-Inflammatory Activities of a Short Molecule, PS14 Derived from the Virulent Cellulose Binding Domain of Aphanomyces invadans, on Human …

M Velayutham, P Sarkar, G Sudhakaran, KA Al-Ghanim… - Molecules, 2022 - mdpi.com
In this study, the anti-cancer and anti-inflammatory activities of PS14, a short peptide derived
from the cellulase binding domain of pathogenic fungus, Aphanomyces invadans, have …

PS9, derived from an aquatic Fungus virulent protein, glycosyl hydrolase, arrests MCF-7 proliferation by regulating intracellular reactive oxygen species and apoptotic …

M Velayutham, P Sarkar, KM Karuppiah… - ACS …, 2023 - ACS Publications
One of the most common diseases in women is breast cancer, which has the highest death
globally. Surgery, chemotherapy, hormone treatments, and radiation are the current …

Antiproliferation of MP12 derived from a fungus, Aphanomyces invadans virulence factor, cysteine-rich trypsin inhibitor on human laryngeal epithelial cells, and in vivo …

M Velayutham, P Sarkar, R Rajakrishnan… - Toxicon, 2022 - Elsevier
Peptide-based drug development is an emerging and promising approach in cancer
therapeutics. The present study focuses on understanding the mechanism of MP12 peptide …

Structure–function engineering of novel fish gelatin-derived multifunctional peptides using high-resolution peptidomics and bioinformatics

A Mirzapour-Kouhdasht, M Moosavi-Nasab, CW Lee… - Scientific Reports, 2021 - nature.com
The multifunctional properties of fish gelatin hydrolysates have not been completely
elucidated. Here, the biological characterization of these peptides was performed to …

Derivation of a novel antimicrobial peptide from the Red Sea Brine Pools modified to enhance its anticancer activity against U2OS cells

M Elradi, AI Ahmed, AM Saleh, KMA Abdel-Raouf… - BMC …, 2024 - Springer
Cancer associated drug resistance is a major cause for cancer aggravation, particularly as
conventional therapies have presented limited efficiency, low specificity, resulting in long …

In silico identification and in vitro assessment of a potential anti-breast cancer activity of antimicrobial peptide retrieved from the ATMP1 Anabas testudineus fish …

D Law, AA Najm, JX Chong, JZY K'ng, M Amran… - PeerJ, 2023 - peerj.com
A previous study has shown that synthetic antimicrobial peptides (AMPs) derived from
Anabas testudineus (ATMP1) could in-vitro inhibit the progression of breast cancer cell lines …

Influence of Fatty Acid Modification on the Anticancer Activity of the Antimicrobial Peptide Figainin 1

Z Han, D Feng, W Wang, Y Wang, M Cheng, H Yang… - ACS …, 2023 - ACS Publications
Antimicrobial peptides derived from the skin secretions of amphibians have made important
progress in tumor therapy due to their unique mechanism of destroying cell membranes …

Tools and techniques for rational designing of antimicrobial peptides for aquaculture

RAH Bhat, D Thakuria, RS Tandel… - Fish & Shellfish …, 2022 - Elsevier
Fisheries and aquaculture industries remain essential sources of food and nutrition for
millions of people worldwide. Indiscriminate use of antibiotics has led to the emergence of …

Antibacterial and antioomycete activities of a novel designed RY12WY peptide against fish pathogens

RAH Bhat, D Thakuria, V Pant, VC Khangembam… - Microbial …, 2020 - Elsevier
In the present study, we have designed and synthesized a short compositionally simple
peptide RY12WY having potent antimicrobial activity. The molecular docking study results …