Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly
used to treat a range of infections. Resistance to these agents is multifactorial and can be via …

Fluoroquinolones are antibacterial drugs that inhibit DNA Gyrase and Topoisomerase IV.
These essential enzymes facilitate chromosome replication and RNA transcription by …

Fluoroquinolones have a broad spectrum of activity for complicated urinary tract infections,
gastrointestinal infections, respiratory tract infections, sexually transmitted diseases, and …

Mechanisms of bacterial resistance to fluoroquinolones fall into two principal categories,
alterations in drug target enzymes and alterations that limit permeation of drug to the target …

Broad use of fluoroquinolones has been followed by emergence of resistance, which has
been due mainly to chromosomal mutations in genes encoding the subunits of the drugs' …

Quinolone antibiotics represent one of the most important classes of anti-infective agents
and, although still clinically valuable, their use has been compromised by the increasing …

Fluoroquinolones are broad-spectrum antimicrobials highly effective for treatment of a
variety of clinical and veterinary infections. Their antibacterial activity is due to inhibition of …

The fluoroquinolones interact with 2 bacterial targets, the related enzymes DNA gyrase and
topoisomerase IV, both of which are involved in DNA replication. Quinolones form …

Quinolone antibiotics constitute a clinically successful and widely used class of broad-
spectrum antibiotics; however, the emergence and spread of resistance increasingly limits …

Quinolone antimicrobials are synthetic and widely used in clinical medicine. Resistance
emerged with clinical use and became common in some bacterial pathogens. Mechanisms …