Cutting edge: circulating exosomes with COVID spike protein are induced by BNT162b2 (Pfizer–BioNTech) vaccination prior to development of antibodies: a novel …

S Bansal, S Perincheri, T Fleming… - The Journal of …, 2021 - journals.aai.org
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes severe acute
respiratory syndrome. mRNA vaccines directed at the SARS-CoV-2 spike protein resulted in …

Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

SJ Tsai, NA Atai, M Cacciottolo, J Nice, A Salehi… - Journal of Biological …, 2021 - ASBMB
Functional delivery of mRNA has high clinical potential. Previous studies established that
mRNAs can be delivered to cells in vitro and in vivo via RNA-loaded lipid nanoparticles …

Possibility of exosome‑based coronavirus disease 2019 vaccine

KH Yoo, N Thapa, BJ Kim, JO Lee… - Molecular …, 2022 - spandidos-publications.com
Abstract Coronavirus disease 2019 (COVID‑19) is a global pandemic that can have a long‑
lasting impact on public health if not properly managed. Ongoing vaccine development trials …

Extracellular vesicles carry SARS‐CoV‐2 spike protein and serve as decoys for neutralizing antibodies

Z Troyer, N Alhusaini, CO Tabler… - Journal of …, 2021 - Wiley Online Library
In late 2019, a novel coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2) emerged in Wuhan, China. SARS‐CoV‐2 and the disease it causes …

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Z Wang, KD Popowski, D Zhu… - Nature biomedical …, 2022 - nature.com
The first two mRNA vaccines against infection by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) that were approved by regulators require a cold chain and …

[HTML][HTML] SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2

F Amanat, M Thapa, T Lei, SMS Ahmed, DC Adelsberg… - Cell, 2021 - cell.com
In this study we profiled vaccine-induced polyclonal antibodies as well as plasmablast-
derived mAbs from individuals who received SARS-CoV-2 spike mRNA vaccine. Polyclonal …

Promising extracellular vesicle-based vaccines against viruses, including SARS-CoV-2

B Sabanovic, F Piva, M Cecati, M Giulietti - Biology, 2021 - mdpi.com
Simple Summary Extracellular vesicles (EVs) allow cell-to-cell communication and can
induce a strong immune response, by presenting antigens. EVs can be engineered to …

Exosome-based vaccines: history, current state, and clinical trials

P Santos, F Almeida - Frontiers in immunology, 2021 - frontiersin.org
Extracellular vesicles (EVs) are released by most cell types as part of an intracellular
communication system in crucial processes such as inflammation, cell proliferation, and …

Cutting edge: nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity

WE Matchett, V Joag, JM Stolley… - The Journal of …, 2021 - journals.aai.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the
COVID-19 pandemic. Neutralizing Abs target the receptor binding domain of the spike (S) …

SARS CoV-2 spike protein-guided exosome isolation facilitates detection of potential miRNA biomarkers in COVID-19 infections

S Mimmi, AM Zimbo, S Rotundo, E Cione… - Clinical Chemistry and …, 2023 - degruyter.com
Objectives Nearly three years into the pandemic, SARS-CoV-2 infections are occurring in
vaccinated and naturally infected populations. While humoral and cellular responses in …