Aging effects on DNA methylation modules in human brain and blood tissue
Background Several recent studies reported aging effects on DNA methylation levels of
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …
Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape
K Day, LL Waite, A Thalacker-Mercer, A West… - Genome biology, 2013 - Springer
Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …
tissues, although the mechanisms and specificity of this process are still poorly understood …
Distinct DNA methylation changes highly correlated with chronological age in the human brain
Methylation at CpG sites is a critical epigenetic modification in mammals. Altered DNA
methylation has been suggested to be a central mechanism in development, some disease …
methylation has been suggested to be a central mechanism in development, some disease …
Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in
humans remains poorly understood. While DNA methylation at many CpG sites closely …
humans remains poorly understood. While DNA methylation at many CpG sites closely …
Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
S Marttila, L Kananen, S Häyrynen, J Jylhävä… - BMC genomics, 2015 - Springer
Background Changes in DNA methylation are among the mechanisms contributing to the
ageing process. We sought to identify ageing-associated DNA methylation changes at …
ageing process. We sought to identify ageing-associated DNA methylation changes at …
Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Continuous aging of the human DNA methylome throughout the human lifespan
Å Johansson, S Enroth, U Gyllensten - PloS one, 2013 - journals.plos.org
DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …
Concordant and discordant DNA methylation signatures of aging in human blood and brain
Background DNA methylation is an epigenetic mark that balances plasticity with stability.
While DNA methylation exhibits tissue specificity, it can also vary with age and potentially …
While DNA methylation exhibits tissue specificity, it can also vary with age and potentially …
[HTML][HTML] Genome-wide methylation profiles reveal quantitative views of human aging rates
The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life …
many fields, including disease prevention and treatment, forensics, and extension of life …
Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites
I Florath, K Butterbach, H Müller… - Human molecular …, 2014 - academic.oup.com
Understanding the role of epigenetic modifications, eg DNA methylation, in the process of
aging requires the characterization of methylation patterns in large cohorts. We analysed> …
aging requires the characterization of methylation patterns in large cohorts. We analysed> …