Bone is one of the most preferential target site for cancer metastases, particularly for
prostate, breast, kidney, lung and thyroid primary tumours. Indeed, numerous chemical …

Bone metastases ultimately result from a complex interaction between cancer cells and
bone microenvironment. However, prior to the colonization of the bone, cancer cells must …

It has been long recognized that skeleton represents one of the most favored metastatic sites
for common cancers like breast and prostate. During the last decade the molecular …

Evidence demonstrated that bones, liver, and lungs are the most common metastasis sites in
some human malignancies, especially in prostate and breast cancers. Bone is the third most …

Background Bone is one of the most common target organs for cancer metastasis, especially
in patients with advanced breast and prostate cancers. Despite recent advances in …

Metastasis is a final stage of tumor progression. Breast and prostate cancer cells
preferentially metastasize to bone, wherein they cause incurable osteolytic and osteoblastic …

As one of the most common metastatic sites of malignancies, bone has a unique
microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated …

Metastatic disease is the cause of death in the majority of cancer patients. Bone marrow is a
preferential site of metastasis in breast and prostate cancer, responsible for the majority of …

Bone metastases are a common complication of epithelial cancers, of which breast, prostate
and lung carcinomas are the most common. The establishment of cancer cells to distant …

The bone microenvironment provides a fertile soil for cancer cells. It is therefore not
surprising that the skeleton is a frequent site of cancer metastasis. It is believed that …