T-cell exhaustion denotes a hypofunctional state of T lymphocytes commonly found in
cancer, but how tumor cells drive T-cell exhaustion remains elusive. Here, we find T-cell …

Understanding cellular metabolism holds immense potential for developing new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …

The accumulation of acidic metabolic waste products within the tumor microenvironment
inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it remains …

Availability of the essential amino acid methionine affects cellular metabolism and growth,
and dietary methionine restriction has been implicated as a cancer therapeutic strategy …

Reversing the dysfunctional T cell state that arises in cancer and chronic viral infections is
the focus of therapeutic interventions; however, current therapies are effective in only some …

CD8+ T cells are central players in controlling infections and cancer. Longevity, functionality,
and metabolic fitness are critical determinants of T cell efficacy in cancer immunotherapy …

Objective Intrahepatic cholangiocarcinoma (ICC) exhibits very low response rate to immune
checkpoint inhibitors (ICIs) and the underlying mechanism is largely unknown. We …

Current immunotherapies yield remarkable clinical outcomes by boosting the power of host
immunity in cancer cell elimination and viral clearance. However, after prolonged antigen …

Objective Methionine metabolism is involved in a myriad of cellular functions, including
methylation reactions and redox maintenance. Nevertheless, it remains unclear whether …

Single-cell RNA-sequencing (scRNA-seq) presents better insights into cell behavior in the
context of a complex tumor microenvironment by profiling single-cell populations. However …