With the continuous development of immunotherapy, researchers have paid more attention
to the specific immune regulatory mechanisms of various immune responses in different …

In the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP)
synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can …

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays
a significant role in health and disease. In this pathway, cGAS, one of the major cytosolic …

The innate immune system protects the host from external pathogens and internal damage
in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP …

Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …

The efficacious detection of pathogens and prompt induction of innate immune signaling
serve as a crucial component of immune defense against infectious pathogens. Over the …

Highlights•Pathogens evade cytosolic DNA sensing using divergent and overlapping
strategies to target cGAS, 2′ 3′-cGAMP, and STING.•Studies of pathogen mechanisms of …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS–STING) signaling
pathway, as vital component of innate immune system, acts a vital role in distinguishing …

Myeloid immune cells (MICs) are potent innate immune cells serving as first responders to
invading pathogens and internal changes to cellular homeostasis. Cancer is a stage of …