Aging is associated with a dysregulation of the immune response, loosely termed
“immunosenescence.” Each part of the immune system is influenced to some extent by the …

The impact of intrinsic aging upon human peripheral blood T cell subsets remains
incompletely quantified and understood. This impact must be distinguished from the …

As individuals age their ability to respond and clear pathogens declines, leading to a greater
incidence and severity of infectious diseases. Additionally, the efficacy of vaccines is …

Until the mid-20th century, infectious diseases were the major cause of morbidity and
mortality in humans. Massive vaccination campaigns, antibiotics, antivirals, and advanced …

Immunosenescence comprises a set of dynamic changes occurring to both, the innate as
well as the adaptive immune system that accompany human aging and result in complex …

Acquired immune function shows recognizable changes over time with organismal aging.
These changes include T-cell dysfunction, which may underlie diminished resistance to …

The T cell compartment undergoes characteristic changes with age, which contribute to
increased incidence and severity of infections and reduced immunogenicity and efficacy of …

The immune system is affected by the aging process and undergoes significant age-related
changes, termed immunosenescence. Different T cell subsets are affected by this process …

The strict limit in proliferative potential of normal human somatic cells–a process known as
replicative senescence–is highly relevant to the immune system, because clonal expansion …

Ageing is accompanied by alterations to T-cell immunity and also by a low-grade chronic
inflammatory state termed inflammaging. The significance of these phenomena is …