Tuning the pharmacokinetic performance of quercetin by cocrystallization

MM Haskins, ON Kavanagh, R Sanii… - Crystal Growth & …, 2023 - ACS Publications
Quercetin (QUE) is a widely studied nutraceutical with a number of potential therapeutic
properties. Although QUE is abundant in the plant kingdom, its poor solubility (≤ 20 μg/mL) …

Cocrystals of quercetin with improved solubility and oral bioavailability

AJ Smith, P Kavuru, L Wojtas… - Molecular …, 2011 - ACS Publications
Flavonoids have been studied extensively due to the observation that diets rich in these
compounds are associated with lower incidences of many diseases. One of the most studied …

Preparation of quercetin–nicotinamide cocrystals and their evaluation under in vivo and in vitro conditions

N Wu, Y Zhang, J Ren, A Zeng, J Liu - RSC advances, 2020 - pubs.rsc.org
Quercetin is a flavonoid abundant in the plant kingdom. Various types of bioactivities of
quercetin have been demonstrated in vitro. Although quercetin has been proposed to exhibit …

Enhancing biopharmaceutical parameters of bioflavonoid quercetin by cocrystallization

K Vasisht, K Chadha, M Karan, Y Bhalla, AK Jena… - …, 2016 - pubs.rsc.org
Quercetin, a polyphenolic nutraceutical belonging to the flavonoid category of natural
compounds, has been extensively studied as an antioxidant, anti-inflammatory, anticancer …

Cocrystals of natural products: Improving the dissolution performance of flavonoids using betaine

Z Zhang, D Li, C Luo, C Huang, R Qiu… - Crystal Growth & …, 2019 - ACS Publications
Flavonoids are a class of important natural chemicals that can be isolated from a wide range
of plants. Flavonoids exhibit diverse pharmacological activities, although most of them are …

Navigating the Complex Solid Form Landscape of the Quercetin Flavonoid Molecule

P Klitou, E Parisi, S Bordignon, F Bravetti… - Crystal Growth & …, 2023 - ACS Publications
Quercetin, a naturally occurring bioflavonoid substance widely used in the nutraceutical and
food industries, exists in various solid forms that can have different physicochemical …

Quercetin amorphous solid dispersions prepared by hot melt extrusion with enhanced solubility and intestinal absorption

X Shi, N Fan, G Zhang, J Sun, Z He… - Pharmaceutical …, 2020 - Taylor & Francis
The aim of this study was to investigate the effect of amorphous solid dispersions (ASDs) on
the dissolution rate and oral bioavailability of Quercetin (Que). First, we prepared the Que …

Bioavailability of quercetin: problems and promises

X Cai, Z Fang, J Dou, A Yu… - Current medicinal …, 2013 - ingentaconnect.com
Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects
including antiinflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against …

Drug design strategies that aim to improve the low solubility and poor bioavailability conundrum in quercetin derivatives

SR Alizadeh, N Savadkouhi… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Scientists are especially interested in polyphenols, particularly flavonoids.
Quercetin, a flavonoid, has demonstrated various therapeutic properties, such as …

Cocrystals of nutraceutical p-coumaric acid with caffeine and theophylline: polymorphism and solid-state stability explored in detail using their crystal graphs

N Schultheiss, M Roe, SXM Boerrigter - CrystEngComm, 2011 - pubs.rsc.org
Cocrystals constructed with p-coumaric acid (a phytochemical and nutraceutical compound)
are investigated with xanthine compounds, caffeine and theophylline. Four cocrystals of p …