Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

Gene regulatory elements, including promoters, enhancers, silencers, etc., control
transcriptional programs in a spatiotemporal manner. Though these elements are known to …

Compared to enhancers, silencers are notably difficult to identify and validate
experimentally. In search for human silencers, we utilized H3K27me3-DNase I …

Silencers are regulatory DNA elements that reduce transcription from their target promoters;
they are the repressive counterparts of enhancers. Although discovered decades ago, and …

The study of gene regulation is dominated by a focus on the control of gene activation or
increase in the level of expression. Just as critical is the process of gene repression or …

Silencers are noncoding DNA sequence fragments located on the genome that suppress
gene expression. The variation of silencers in specific cells is closely related to gene …

The majority of the human genome does not encode proteins. Many of these noncoding
regions contain important regulatory sequences that control gene expression. To date, most …

Silencers and enhancer-blockers (EBs) are cis-acting, negative regulatory elements (NREs)
that control interactions between promoters and enhancers. Although relatively …

Dual-function regulatory elements (REs), acting as enhancers in some cellular contexts and
as silencers in others, have been reported to facilitate the precise gene regulatory response …

It has been over a decade since the first observation that small non-coding RNAs can
functionally modulate epigenetic states in human cells to achieve functional transcriptional …