Currently, two main cell culture models predominate pluripotent stem cell research:
embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Thanks to their …

Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

Embryonic stem cells (ESCs) are derived from the pre-implantation mammalian blastocyst.
At this point in time, the newly formed embryo is concerned with the generation and …

Unlike pluripotent cells, which generate only embryonic tissues, totipotent cells can generate
a full organism, including extra-embryonic tissues. A rare population of cells resembling 2 …

The 21st century started with an important discovery that a pluripotent stem cell can be
induced from differentiated cells by 'simply'introducing a few transcription factors. Because …

In mammals, pluripotent stem cells can give rise to every cell type of embryonic lineage, and
hold great potential in regenerative medicine and disease modeling. Guided by the …

Multicellular organisms develop from a single cell, the zygote. This feature is referred to as
totipotency. In the mouse, only the zygote and the 2-cell stage embryo display this attribute …

Totipotent cells in early embryos are progenitors of all stem cells and are capable of
developing into a whole organism, including extraembryonic tissues such as placenta …

The recent derivation of pluripotent stem cell lines from a number of different sources,
including reprogrammed adult somatic cells, raises the issue of the developmental …

Pluripotent stem cells are thought of as a surrogate of early developmental stages that
sustain the capacity to generate all cell types in the body, thereby constituting an invaluable …