Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

J Zeng, F Weissmann, AP Bertolin, V Posse… - Biochemical …, 2021 - portlandpress.com
The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health challenge …

[HTML][HTML] Therapeutic potential of compounds targeting SARS-CoV-2 helicase

MTJ Halma, MJA Wever, S Abeln, D Roche… - Frontiers in …, 2022 - frontiersin.org
The economical and societal impact of COVID-19 has made the development of vaccines
and drugs to combat SARS-CoV-2 infection a priority. While the SARS-CoV-2 spike protein …

Discovery of COVID-19 inhibitors targeting the SARS-CoV-2 Nsp13 helicase

MA White, W Lin, X Cheng - The journal of physical chemistry …, 2020 - ACS Publications
The raging COVID-19 pandemic caused by SARS-CoV-2 has infected tens of millions of
people and killed several hundred thousand patients worldwide. Currently, there are no …

Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro

L Lu, Y Peng, H Yao, Y Wang, J Li, Y Yang, Z Lin - Antiviral Research, 2022 - Elsevier
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) helicase NSP13 plays
a conserved role in the replication of coronaviruses and has been identified as an ideal …

[HTML][HTML] In Silico Binding of 2-Aminocyclobutanones to SARS-CoV-2 Nsp13 Helicase and Demonstration of Antiviral Activity

TSH Mohammad, Y Gupta, CT Reidl… - International journal of …, 2023 - mdpi.com
The landscape of viral strains and lineages of SARS-CoV-2 keeps changing and is currently
dominated by Delta and Omicron variants. Members of the latest Omicron variants, including …

Natural compounds inhibit SARS-CoV-2 nsp13 unwinding and ATPase enzyme activities

A Corona, K Wycisk, C Talarico, C Manelfi… - ACS pharmacology & …, 2022 - ACS Publications
SARS-CoV-2 infection is still spreading worldwide, and new antiviral therapies are an urgent
need to complement the approved vaccine preparations. SARS-CoV-2 nps13 helicase is a …

[HTML][HTML] Targeting SARS-CoV-2 Nsp13 helicase and assessment of druggability pockets: Identification of two potent inhibitors by a multi-site in silico drug repurposing …

I Romeo, FA Ambrosio, G Costa, A Corona, M Alkhatib… - Molecules, 2022 - mdpi.com
The SARS-CoV-2 non-structural protein 13 (nsp13) helicase is an essential enzyme for viral
replication and has been identified as an attractive target for the development of new …

[HTML][HTML] Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

JA Newman, A Douangamath, S Yadzani… - Nature …, 2021 - nature.com
There is currently a lack of effective drugs to treat people infected with SARS-CoV-2, the
cause of the global COVID-19 pandemic. The SARS-CoV-2 Non-structural protein 13 …

Should we try SARS-CoV-2 helicase inhibitors for COVID-19 therapy?

S Habtemariam, SF Nabavi, M Banach… - Archives of medical …, 2020 - Elsevier
The discovery of new drugs for treating the new coronavirus (SARS-CoV-2) or repurposing
those already in use for other viral infections is possible through understanding of the viral …

Kinetic characterization of SARS-CoV-2 nsp13 ATPase activity and discovery of small-molecule inhibitors

AK Yazdi, P Pakarian, S Perveen, T Hajian… - ACS Infectious …, 2022 - ACS Publications
SARS-CoV-2 non-structural protein 13 (nsp13) is a highly conserved helicase and RNA 5′-
triphosphatase. It uses the energy derived from the hydrolysis of nucleoside triphosphates …