The short-chain fatty acid acetate in body weight control and insulin sensitivity

MA González Hernández, EE Canfora, JWE Jocken… - Nutrients, 2019 - mdpi.com
The interplay of gut microbiota, host metabolism, and metabolic health has gained increased
attention. Gut microbiota may play a regulatory role in gastrointestinal health, substrate …

Acetate: a diet-derived key metabolite in energy metabolism: good or bad in context of obesity and glucose homeostasis?

EE Canfora, EE Blaak - Current Opinion in Clinical Nutrition & …, 2017 - journals.lww.com
Overall, animal and human data suggest a direct regulatory role of acetate in several
pathways involved in energy expenditure and fat utilization. In addition, acetate stimulates …

Short-chain fatty acids in control of body weight and insulin sensitivity

EE Canfora, JW Jocken, EE Blaak - Nature Reviews Endocrinology, 2015 - nature.com
The connection between the gut microbiota and the aetiology of obesity and cardiometabolic
disorders is increasingly being recognized by clinicians. Our gut microbiota might affect the …

Gut microbial-derived short chain fatty acids: impact on adipose tissue physiology

KS May, LJ den Hartigh - Nutrients, 2023 - mdpi.com
Obesity is a global public health issue and major risk factor for pathological conditions,
including type 2 diabetes, dyslipidemia, coronary artery disease, hepatic steatosis, and …

Short chain fatty acids in human gut and metabolic health

EE Blaak, EE Canfora, S Theis, G Frost… - Beneficial …, 2020 - wageningenacademic.com
Evidence is accumulating that short chain fatty acids (SCFA) play an important role in the
maintenance of gut and metabolic health. The SCFA acetate, propionate and butyrate are …

Circulating levels of the short-chain fatty acid acetate mediate the effect of the gut microbiome on visceral fat

A Nogal, P Louca, X Zhang, PM Wells… - Frontiers in …, 2021 - frontiersin.org
Background Acetate is a short-chain fatty acid (SCFA) produced by gut bacteria, which has
been implicated in cardio-metabolic health. Here we examine the relationships of circulating …

Gut microbiota and energy balance: role in obesity

M Blaut - Proceedings of the Nutrition Society, 2015 - cambridge.org
The microbial community populating the human digestive tract has been linked to the
development of obesity, diabetes and liver diseases. Proposed mechanisms on how the gut …

Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism

DJ Morrison, T Preston - Gut microbes, 2016 - Taylor & Francis
The formation of SCFA is the result of a complex interplay between diet and the gut
microbiota within the gut lumen environment. The discovery of receptors, across a range of …

Short-chain fatty acids in control of energy metabolism

J Hu, S Lin, B Zheng, PCK Cheung - Critical reviews in food …, 2018 - Taylor & Francis
Short-chain fatty acids (SCFAs), especially acetate, propionate and butyrate, are the end
products from the intestinal microbial fermentation of dietary fibers and resistant starch. It has …

Gut microbiota and short chain fatty acids: implications in glucose homeostasis

P Portincasa, L Bonfrate, M Vacca… - International journal of …, 2022 - mdpi.com
Gut microbiota encompasses a wide variety of commensal microorganisms consisting of
trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with …