[HTML][HTML] From barriers to novel strategies: smarter CAR T therapy hits hard to tumors
Chimeric antigen receptor (CAR) T cell therapy for solid tumors shows promise, but several
hurdles remain. Strategies to overcome barriers such as CAR T therapy-related toxicities …
hurdles remain. Strategies to overcome barriers such as CAR T therapy-related toxicities …
Increasing the safety and efficacy of chimeric antigen receptor T cell therapy
H Li, Y Zhao - Protein & cell, 2017 - academic.oup.com
Chimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment that has
recently been undergoing rapid development. However, there are still some major …
recently been undergoing rapid development. However, there are still some major …
[HTML][HTML] CAR T cells in solid tumors: blueprints for building effective therapies
HM Knochelmann, AS Smith, CJ Dwyer… - Frontiers in …, 2018 - frontiersin.org
Genetic redirection of T lymphocytes with chimeric antigen receptors (CARs) has soared
from treating cancers preclinically to FDA approval for hematologic malignancies and …
from treating cancers preclinically to FDA approval for hematologic malignancies and …
[HTML][HTML] Recent advances in solid tumor CAR-T cell therapy: driving tumor cells from hero to zero?
P Safarzadeh Kozani, P Safarzadeh Kozani… - Frontiers in …, 2022 - frontiersin.org
Chimeric antigen receptor T-cells (CAR-Ts) are known as revolutionary living drugs that
have turned the tables of conventional cancer treatments in certain hematologic …
have turned the tables of conventional cancer treatments in certain hematologic …
Tumor antigen escape from CAR T-cell therapy
RG Majzner, CL Mackall - Cancer discovery, 2018 - AACR
Emerging data from chimeric antigen receptor (CAR) T-cell trials in B-cell malignancies
demonstrate that a common mechanism of resistance to this novel class of therapeutics is …
demonstrate that a common mechanism of resistance to this novel class of therapeutics is …
Chimeric antigen receptor T cell and regulatory T cell therapy in non-oncology diseases: A narrative review of studies from 2017 to 2023
MY Sun, W Li, W Chen - Human Vaccines & Immunotherapeutics, 2023 - Taylor & Francis
Recently, the remarkable success of chimeric antigen receptor T cell (CAR-T) therapy in
treating certain tumors has led to numerous studies exploring its potential application to treat …
treating certain tumors has led to numerous studies exploring its potential application to treat …
Chimeric antigen receptor T-cell therapy: reach to solid tumor experience
MN Metzinger, C Verghese, DM Hamouda, A Lenhard… - Oncology, 2019 - karger.com
Chimeric antigen receptor (CAR) modified T-cell therapy, a unique platform technology
highlighting precision medicine through utilization of molecular biology and cell-based …
highlighting precision medicine through utilization of molecular biology and cell-based …
[HTML][HTML] Hurdles to breakthrough in CAR T cell therapy of solid tumors
Autologous T cells genetically engineered to express chimeric antigen receptor (CAR) have
shown promising outcomes and emerged as a new curative option for hematological …
shown promising outcomes and emerged as a new curative option for hematological …
[HTML][HTML] T cell engaging immunotherapies, highlighting chimeric antigen receptor (CAR) T cell therapy
E De Bousser, N Callewaert, N Festjens - Cancers, 2021 - mdpi.com
Simple Summary The ultimate goal of T cell-engaging immunotherapy is to endorse the
activity of a person's own cytotoxic T cells in the tumor microenvironment, finally destroying …
activity of a person's own cytotoxic T cells in the tumor microenvironment, finally destroying …
INSPIRED Symposium Part 4B: Chimeric Antigen Receptor T Cell Correlative Studies—Established Findings and Future Priorities
Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of B cell
malignancies, with multiple CAR T cell products approved for numerous indications by …
malignancies, with multiple CAR T cell products approved for numerous indications by …