Lymphokine control of in vivo immunoglobulin isotype selection
FD Finkelman, J Holmes, IM Katona… - Annual review of …, 1990 - annualreviews.org
The discovery by Isakson and Vitetta that a T lymphocyte-produced substance could induce
lipopolysaccharide (LPS)-activated murine B lym phocytes to secrete IgG 1 (1) demonstrated …
lipopolysaccharide (LPS)-activated murine B lym phocytes to secrete IgG 1 (1) demonstrated …
IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.
FD Finkelman, IM Katona, TR Mosmann… - Journal of immunology …, 1988 - journals.aai.org
The lymphokine IFN-gamma has been shown in vitro to stimulate IgG2a secretion and inhibit
IgG1 and IgE secretion by LPS-activated B lymphocytes. To determine whether IFN-gamma …
IgG1 and IgE secretion by LPS-activated B lymphocytes. To determine whether IFN-gamma …
Regulation by interferon alpha of immunoglobulin isotype selection and lymphokine production in mice.
FD Finkelman, A Svetic, I Gresser, C Snapper… - The Journal of …, 1991 - rupress.org
Antigens and infectious agents that stimulate interferon alpha (IFN-alpha) production in mice
induce antibody responses that are predominantly of the immunoglobulin (Ig) G2a isotype …
induce antibody responses that are predominantly of the immunoglobulin (Ig) G2a isotype …
Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures.
DA Lebman, RL Coffman - The Journal of experimental medicine, 1988 - rupress.org
Although it has been established that IL-4 enhances both IgG1 and IgE secretion in LPS-
stimulated B cell cultures, these studies failed to determine whether IL-4 preferentially …
stimulated B cell cultures, these studies failed to determine whether IL-4 preferentially …
[引用][C] Regulation of IgG1 and IgE production by interleukin 4
CM Snapper, FD Finkelman, WE Paul - Immunological reviews, 1988 - Wiley Online Library
The immunoglobulin (Ig) class switch is a process critical for the generation of funclional
diversity of antibodies of a given specificity. Ig class (isotypw) is defined by ihe Fc portion o'f …
diversity of antibodies of a given specificity. Ig class (isotypw) is defined by ihe Fc portion o'f …
Regulation of IgA differentiation in CH12LX B cells by lymphokines. IL-4 induces membrane IgM-positive CH12LX cells to express membrane IgA and IL-5 induces …
DY Kunimoto, GR Harriman… - Journal of immunology …, 1988 - journals.aai.org
In these studies we utilized the Ag (SRBC)-reactive B cell line CH12LX to study isotype
switching. CH12LX cells are a stable population of B cells mainly bearing membrane IgM …
switching. CH12LX cells are a stable population of B cells mainly bearing membrane IgM …
Interleukin 5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin (Ig) G1 and IgE.
JM Purkerson, PC Isakson - The Journal of experimental medicine, 1992 - rupress.org
We have examined the contributions of Interleukin 4 (IL-4), IL-5, and other stimuli to the
expression of Immunoglobulin G1 (IgG1) and IgE in murine B lymphoblasts activated with …
expression of Immunoglobulin G1 (IgG1) and IgE in murine B lymphoblasts activated with …
IFN-γ enhances secretion of IgG2a from IgG2a-committed LPS-stimulated murine B cells: implications for the role of IFN-γ in class switching
A Bossie, ES Vitetta - Cellular immunology, 1991 - Elsevier
IFN-γ is a pleiotropic lymphokine that influences the isotypes of immunoglobulin secreted by
B cells. IFN-γ inhibits the secretion of IgG3, IgG2b, IgG1, and IgE, and enhances the …
B cells. IFN-γ inhibits the secretion of IgG3, IgG2b, IgG1, and IgE, and enhances the …
Regulation of human IgG subclass production by cytokines. IFN-gamma and IL-6 act antagonistically in the induction of human IgG1 but additively in the induction of …
Y Kawano, T Noma, J Yata - Journal of immunology (Baltimore, Md …, 1994 - journals.aai.org
In this study, we investigated the roles of IFN-gamma and IL-6 in the induction of IgG
subclasses from PBMC stimulated with PWM. The presence of IFN-gamma in the first half of …
subclasses from PBMC stimulated with PWM. The presence of IFN-gamma in the first half of …
Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4.
S Gerondakis - Proceedings of the National Academy of …, 1990 - National Acad Sciences
The murine lymphokine, interleukin 4 (IL-4) is able to specifically promote isotype switching
to IgG1 and IgE in cultures of mitogen-stimulated B cells. Emerging evidence suggests that …
to IgG1 and IgE in cultures of mitogen-stimulated B cells. Emerging evidence suggests that …