Renal handling of albumin—from early findings to current concepts

J Gburek, B Konopska, K Gołąb - International journal of molecular …, 2021 - mdpi.com
Albumin is the main protein of blood plasma, lymph, cerebrospinal and interstitial fluid. The
protein participates in a variety of important biological functions, such as maintenance of …

Renal handling of albumin: a critical review of basic concepts and perspective

LM Russo, GL Bakris, WD Comper - American journal of kidney diseases, 2002 - Elsevier
Biochemical and physiological processes that underlie the mechanism of albuminuria are
completely reassessed in this article in view of recent discoveries that filtered proteins …

Retention of albumin in the circulation is governed by saturable renal cell-mediated processes

M Koltun, WD Comper - Microcirculation, 2004 - Taylor & Francis
Objective: To examine the role of renal processing in the turnover of circulating albumin in
the model of reversible overload proteinuria. Specifically, this study determines whether …

Integrative role of albumin: evolutionary, biochemical and pathophysiological aspects

DA Belinskaia, PA Voronina, NV Goncharov - Journal of evolutionary …, 2021 - Springer
Being one of the main proteins in the human body and many animal species, albumin plays
a crucial role in the transport of various ions, electrically neutral molecules and in …

[HTML][HTML] Renal albumin absorption in physiology and pathology

H Birn, EI Christensen - Kidney international, 2006 - Elsevier
Albumin is the most abundant plasmaprotein serving multiple functions as a carrier of
metabolites, hormones, vitamins, and drugs, as an acid/base buffer, as antioxidant and by …

Albumin transport and processing by the proximal tubule: physiology and pathophysiology

CA Pollock, P Poronnik - Current opinion in nephrology and …, 2007 - journals.lww.com
Albumin transport and processing by the proximal tubule: phy... : Current Opinion in
Nephrology and Hypertension Albumin transport and processing by the proximal tubule …

Characterization of the urinary albumin degradation pathway in the isolated perfused rat kidney

LM Hilliard, TM Osicka, SP Clavant… - Journal of Laboratory …, 2006 - Elsevier
This study examines the existence of the urinary albumin degradation pathway and the
proposed role of receptor-mediated endocytosis in this process using the isolated perfused …

New insights into proteinuria/albuminuria

WD Comper, J Vuchkova, KJ McCarthy - Frontiers in Physiology, 2022 - frontiersin.org
The fractional clearance of proteins as measured in healthy human subjects increases
10,000–100,000-fold when studied in nephrotic patients. This remarkable increase cannot …

Renal tubule albumin transport

M Gekle - Annu. Rev. Physiol., 2005 - annualreviews.org
▪ Abstract Albumin is the most abundant protein in serum and contributes to the maintenance
of oncotic pressure as well as to transport of hydrophobic molecules. Although albumin is a …

[HTML][HTML] The return of glomerular-filtered albumin to the rat renal vein

GA Eppel, TM Osicka, LM Pratt, P Jablonski… - Kidney international, 1999 - Elsevier
The return of glomerular-filtered albumin to the rat renal vein. Background Recent studies
have demonstrated that the normal glomerular capillary wall (GCW) is not charge selective …