In response to a surge of deaths from synthetic opioid overdoses, there have been
increased efforts to distribute naloxone products in community settings. Prior research has …

Opioids are effective analgesics, but they can have harmful adverse effects, such as
addiction and potentially fatal respiratory depression. Naloxone is currently the only …

Background Opioid-induced respiratory depression is antagonized effectively by the
competitive opioid receptor antagonist naloxone. However, to fully understand the complex …

Introduction Opioid abuse and opioid overdose deaths have increased significantly over the
past decade. Naloxone is a potentially life-saving medication that can reverse opioid …

Respiratory depression is the proximal cause of death in opioid overdose, yet the
mechanisms underlying this potentially fatal outcome are not well understood. The goal of …

Opioid-induced respiratory depression (OIRD) deaths are~ 80,000 a year in the US and are
a major public health issue. Approximately 90% of fatal opioid-related deaths are due to …

Background Opioids are potent painkillers but come with serious adverse effects ranging
from addiction to potentially lethal respiratory depression. A variety of drugs with separate …

Background One of the most prominent opioid analgesics in the United States is the high
potency agonist fentanyl. It is used in the treatment of acute and chronic pain and as an …

Opioids may produce life-threatening respiratory depression and death from their actions at
the opioid receptors within the brainstem respiratory neuronal network. Since there is an …

Introduction: Opioid overdose fatality has increased threefold since 1999. As a result,
prescription drug overdose surpassed motor vehicle collision as the leading cause of …