Elevated CD47 expression in some cancers is associated with decreased survival and
limited clearance by phagocytes expressing the CD47 counterreceptor SIRPα. In contrast …

CD47, a “don't eat me” signal for phagocytic cells, is expressed on the surface of all human
solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue …

Objective: Integrin-associated protein (CD47) binds specifically to the inhibitory receptor
signal-regulatory protein. This study was designed to evaluate the role of CD47 in natural …

Tumor immunosurveillance is a well-established mechanism for regulation of tumor growth.
In this regard, most studies have focused on the role of T-and NK-cells as the critical immune …

Macrophages are often the most abundant immune cell found in the tumor
microenvironment, but are frequently associated with poor patient prognosis and considered …

Antibodies that bind CD47 on tumor cells and prevent interaction with SIRPα on phagocytes
are active against multiple cancer types including T-cell lymphoma (TCL). Here we …

ABSTRACT CD47 has established roles in the immune system for regulating macrophage
phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory …

CD47, a broadly expressed cell surface protein, inhibits cell phagocytosis via interaction
with phagocyte-expressed SIRPα. A variety of hematological malignancies demonstrate …

CD47 is an antiphagocytic ligand broadly expressed on normal and malignant tissues that
delivers an inhibitory signal through the receptor signal regulatory protein alpha (SIRPα) …

The treatment of breast cancer largely depends on the utilization of immunogenic
chemotherapeutics, which, as a common leitmotif, stimulate the exposure of calreticulin …