Endogenous adenosine is produced by the heart during ischemia-reperfusion as a natural
cardioprotectant. The benefits of this local protective mechanism can be harnessed by …

Adenosine is released from the myocardium in response to a decrease in the oxygen
supply/demand ratio, as is seen in myocardial ischemia; its protective role is manifested by …

Cells of the cardiovascular system generate and release purine nucleoside adenosine in
increasing quantities when constituent cells are “stressed” or subjected to injurious stimuli …

BACKGROUND We hypothesized that 1) endogenous adenosine released during ischemia
conferred an inherent cardioprotection, and 2) a pretreatment dose of adenosine before …

Adenosine is released in large amounts during myocardial ischemia and is capable of
exerting potent cardioprotective effects in the heart. Although these observations on …

Prevention and attenuation of ischemia and reperfusion injury in patients with acute
coronary syndrome are critically important for cardiologists. To save these patients from …

Adenosine exerts cardioprotrective effects on the ischemic myocardium. A flexibly mounted
microdialysis probe was used to measure the concentration of interstitial adenosine and to …

Adenosine is a ubiquitous extracellular signaling molecule with essential functions in human
physiology. Due to the widespread expression of adenosine receptors, it has far-reaching …

The effects of adenosine in the nonischemic heart have been shown to be mediated via its
binding to extracellular adenosine A1 and A2 receptors located predominantly on myocytes …

Ischemic heart disease includes a number of entities that have been grouped in accordance
with physiopathology and evolutive criteria. In recent years 'new'ischemic syndromes have …