The liver is a multifunctional organ that plays crucial roles in numerous physiological
processes, such as production of bile and proteins for blood plasma, regulation of blood …

The liver is a site of complex immune activity. The hepatic immune system tolerates
harmless immunogenic loads in homeostasis status, shelters liver function, while …

The human liver is usually perceived as a non-immunological organ engaged primarily in
metabolic, nutrient storage and detoxification activities. However, we now know that the …

The tight relationship between the gut and liver on embryological, anatomical and
physiological levels inspired the concept of a gut-liver axis as a central element in the …

Highlights•The liver has unique immune functions.•Organ-resident cells contribute to
regulation of antigen-specific immunity by functioning as antigen-presenting cells.•Different …

The anatomical architecture of the human liver and the diversity of its immune components
endow the liver with its physiological function of immune competence. Adaptive immunity is …

Communication between organs participates in most physiological and pathological events.
Owing to the importance of precise coordination among the liver and virtually all organs in …

The human liver is an organ with a diverse array of immunologic functions. Its unique
anatomic position that leads to it receiving all the mesenteric venous blood, combined with …

The gut-liver axis covers the bidirectional communication between the gut and the liver, and
thus includes signals from liver-to-gut (eg, bile acids, immunoglobulins) and from gut-to-liver …

Five years ago, we launched a special issue in the Cellular & Molecular Immunology with a
focus on basic liver immunology, which included eight review articles covering the …