A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus mapping and …

This white paper by eighty members of the Complex Trait Consortium presents a
community's view on the approaches and statistical analyses that are needed for the …

One of the great conflicts in the history of genetics was reconciled with the realization that
continuous variation in phenotype could reflect the net effects of a large number of genes. In …

▪ Abstract Phenotypic variation for quantitative traits results from the segregation of alleles at
multiple quantitative trait loci (QTL) with effects that are sensitive to the genetic, sexual, and …

Understanding the molecular basis of quantitative genetic variation is a principal goal for
biomedicine. Although the complex genetic architecture of quantitative traits has so far …

Until recently, it was impracticable to identify the genes that are responsible for variation in
continuous traits, or to directly observe the effects of their different alleles. Now, the …

Background Correlations between polymorphic markers and observed phenotypes provide
the basis for mapping traits in quantitative genetics. When the phenotype is gene …

The development of any organism is a complex dynamic process that is controlled by a
network of genes as well as by environmental factors. Traditional mapping approaches for …

The biological mechanisms that link genetic variation and its phenotypic outcome stand as a
central puzzle in biology. Geneticists have usually approached this problem by trying to …

We compare and contrast the genetic architecture of quantitative phenotypes in two
genetically well-characterized model organisms, the laboratory mouse, Mus musculus, and …