A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

Y Zhao, L Sui, P Wu, W Wang, Z Wang, Y Yu… - … and Targeted Therapy, 2021 - nature.com
The recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of ongoing global pandemic of COVID-19, may trigger …

SARS-CoV-2 nucleocapsid protein targets RIG-I-like receptor pathways to inhibit the induction of interferon response

SJ Oh, OS Shin - Cells, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the coronavirus disease 2019 (COVID-19) that has resulted in the current pandemic. The …

The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development

H Yu, F Guan, H Miller, J Lei, C Liu - Emerging microbes & …, 2023 - Taylor & Francis
ABSTRACT The coronavirus disease 2019 (COVID-19) has caused enormous health risks
and global economic disruption. This disease is caused by the severe acute respiratory …

[HTML][HTML] Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation

W Wang, J Chen, X Yu, HY Lan - International journal of biological …, 2022 - ncbi.nlm.nih.gov
COVID-19 which is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-
2) has posed a worldwide pandemic and a major global public health threat. SARS-CoV-2 …

SARS-CoV-2 nucleocapsid protein interacts with RIG-I and represses RIG-mediated IFN-β production

K Chen, F Xiao, D Hu, W Ge, M Tian, W Wang, P Pan… - Viruses, 2020 - mdpi.com
SARS-CoV-2 is highly pathogenic in humans and poses a great threat to public health
worldwide. Clinical data shows a disturbed type I interferon (IFN) response during the virus …

[HTML][HTML] SARS-CoV-2 spike antagonizes innate antiviral immunity by targeting interferon regulatory factor 3

RS Freitas, TF Crum, K Parvatiyar - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Corona virus disease 2019 (COVID-19) pathogenesis is intimately linked to the severe acute
respiratory syndrome corona virus 2 (SARS-CoV-2) and disease severity has been …

SARS‐CoV‐2 NSP8 suppresses type I and III IFN responses by modulating the RIG‐I/MDA5, TRIF, and STING signaling pathways

J Deng, SN Zheng, Y Xiao, ML Nan… - Journal of Medical …, 2023 - Wiley Online Library
SARS‐CoV‐2 has developed a variety of approaches to counteract host innate antiviral
immunity to facilitate its infection, replication and pathogenesis, but the molecular …

The molecular mechanism of SARS-CoV-2 evading host antiviral innate immunity

W Gu, H Gan, Y Ma, L Xu, ZJ Cheng, B Li, X Zhang… - Virology journal, 2022 - Springer
Abstract The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) has resulted in a global health emergency (COVID-19) because of its rapid spread …

Activation and evasion of type I interferon responses by SARS-CoV-2

X Lei, X Dong, R Ma, W Wang, X Xiao, Z Tian… - Nature …, 2020 - nature.com
The pandemic of COVID-19 has posed an unprecedented threat to global public health.
However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host …

[HTML][HTML] Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) and spike (S) proteins antagonize host type I interferon response

Q Zhang, Z Chen, C Huang, J Sun, M Xue… - Frontiers in Cellular …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has spread worldwide and has infected more than 250 million …