[HTML][HTML] SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates

S Shimizu, M Nakayama, CT Nguyen, H Ishigaki… - Journal of …, 2024 - Elsevier
We examined the histopathological changes in the olfactory mucosa of cynomolgus and
rhesus macaque models of SARS-CoV-2 infection. SARS-CoV-2 infection induced severe …

Severe acute respiratory syndrome coronavirus 2 infects and damages the mature and immature olfactory sensory neurons of hamsters

AJ Zhang, ACY Lee, H Chu, JFW Chan… - Clinical infectious …, 2021 - academic.oup.com
Abstract Background Coronavirus disease 2019 (COVID-19) is primarily an acute respiratory
tract infection. Distinctively, a substantial proportion of COVID-19 patients develop olfactory …

[HTML][HTML] Oral SARS-CoV-2 inoculation causes nasal viral infection leading to olfactory bulb infection: an experimental study

R Ueha, T Ito, R Furukawa, M Kitabatake… - Frontiers in cellular …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections can cause long-
lasting anosmia, but the impact of SARS-CoV-2 infection, which can spread to the nasal …

COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters

GD De Melo, F Lazarini, S Levallois… - Science translational …, 2021 - science.org
Whereas recent investigations have revealed viral, inflammatory, and vascular factors
involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung …

New insights into SARS-CoV-2 brain infection and olfactory impairment in the hamster model

J Ferreira - Lab Animal, 2023 - nature.com
Many people are still being infected with COVID-19, and many more are still suffering from
its long-lasting effects. Despite a large amount of research on the mechanisms that explain …

Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit

M Kishimoto-Urata, S Urata, R Kagoya, F Imamura… - Scientific reports, 2022 - nature.com
The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points
using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory …

Olfactory immune response to SARS-CoV-2

SA Wellford, EA Moseman - Cellular & Molecular Immunology, 2024 - nature.com
Numerous pathogens can infect the olfactory tract, yet the pandemic caused by SARS-CoV-
2 has strongly emphasized the importance of the olfactory mucosa as an immune barrier …

Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

B Bryche, A St Albin, S Murri, S Lacôte, C Pulido… - Brain, behavior, and …, 2020 - Elsevier
Anosmia is one of the most prevalent symptoms of SARS-CoV-2 infection during the COVID-
19 pandemic. However, the cellular mechanism behind the sudden loss of smell has not yet …

COVID-19-associated olfactory dysfunction reveals SARS-CoV-2 neuroinvasion and persistence in the olfactory system

GD De Melo, F Lazarini, S Levallois, C Hautefort… - BioRxiv, 2020 - biorxiv.org
While recent investigations have revealed viral, inflammatory and vascular factors involved
in SARS-CoV-2 lung pathogenesis, the pathophysiology of neurological disorders in COVID …

Inflammatory response and defects on myelin integrity in the olfactory system of K18hACE2 mice infected with SARS-CoV-2

E Martin-Lopez, B Brennan, T Mao, N Spence… - eneuro, 2024 - eneuro.org
Viruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), use
respiratory epithelial cells as an entry point for infection. Within the nasal cavity, the olfactory …