Withaferin A: A potential therapeutic agent against COVID-19 infection
AR Straughn, SS Kakar - Journal of Ovarian Research, 2020 - Springer
The outbreak and continued spread of the novel coronavirus disease 2019 (COVID-19) is a
preeminent global health threat that has resulted in the infection of over 11.5 million people …
preeminent global health threat that has resulted in the infection of over 11.5 million people …
Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish …
Purpose SARS-CoV-2 engages human ACE2 through its spike (S) protein receptor binding
domain (RBD) to enter the host cell. Recent computational studies have reported that …
domain (RBD) to enter the host cell. Recent computational studies have reported that …
Down-regulation of estrogen receptor-alpha and rearranged during transfection tyrosine kinase is associated with withaferin a-induced apoptosis in MCF-7 breast …
X Zhang, R Mukerji, AK Samadi, MS Cohen - BMC complementary and …, 2011 - Springer
Abstract Background Withaferin A (WA), a naturally occurring withanolide, induces apoptosis
in both estrogen-responsive MCF-7 and estrogen-independent MDA-MB-231 breast cancer …
in both estrogen-responsive MCF-7 and estrogen-independent MDA-MB-231 breast cancer …
Withanone from Withania somnifera may inhibit novel coronavirus (COVID-19) entry by disrupting interactions between viral S-protein receptor binding domain and …
Background Newly emerged COVID-19 has been shown to engage the host cell ACE2
through its spike protein receptor binding domain (RBD). Here we show that natural …
through its spike protein receptor binding domain (RBD). Here we show that natural …
Eltrombopag is a potential target for drug intervention in SARS-CoV-2 spike protein
S Feng, X Luan, Y Wang, H Wang, Z Zhang… - Infection, Genetics and …, 2020 - Elsevier
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2), is a current global threat for which there is an urgent need to search for an …
(SARS-CoV-2), is a current global threat for which there is an urgent need to search for an …
Potential influence of COVID-19/ACE2 on the female reproductive system
Y Jing, L Run-Qian, W Hao-Ran… - Molecular human …, 2020 - academic.oup.com
Abstract The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then
spread throughout the world rapidly. The virus invades the target cell by binding to …
spread throughout the world rapidly. The virus invades the target cell by binding to …
[HTML][HTML] A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells
Y Wang, Y Wang, W Luo, L Huang, J Xiao… - … journal of medical …, 2020 - ncbi.nlm.nih.gov
The outbreak of pneumonia caused by SARS-CoV-2 posed a great threat to global human
health, which urgently requires us to understand comprehensively the mechanism of SARS …
health, which urgently requires us to understand comprehensively the mechanism of SARS …
Withania somnifera as a potential future drug molecule for COVID-19
Conclusion Together, the literature strongly suggests that derivatives of W. somnifera can
bind to the key targets (Spike protein, ACE-2, RdRp, 3CLpro and PLpro) of SARS-CoV-2 …
bind to the key targets (Spike protein, ACE-2, RdRp, 3CLpro and PLpro) of SARS-CoV-2 …
Withaferin a alone and in combination with cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cells
SS Kakar, MZ Ratajczak, KS Powell… - PloS one, 2014 - journals.plos.org
Currently, the treatment for ovarian cancer entails cytoreductive surgery followed by
chemotherapy, mainly, carboplatin combined with paclitaxel. Although this regimen is …
chemotherapy, mainly, carboplatin combined with paclitaxel. Although this regimen is …
ACE2 as a potential therapeutic target for pandemic COVID-19
B Chatterjee, SS Thakur - RSC advances, 2020 - pubs.rsc.org
SARS-CoV-2 virus invades the host through angiotensin-converting enzyme 2 (ACE2)
receptors by decreasing the ACE2 expression of the host. This disturbs the dynamic …
receptors by decreasing the ACE2 expression of the host. This disturbs the dynamic …