The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …

The discovery that stress and depression, as well as other psychiatric illnesses, are
characterized by structural alterations, and that these changes result from atrophy and loss …

Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

Depression is associated with structural alterations in limbic brain regions that control
emotion and mood. Studies of chronic stress in animal models and postmortem tissue from …

Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …

Stressful life events impact on memory, cognition and emotional responses, and are known
to precipitate mood/anxiety disorders. It is increasingly recognized that stress and its …

Depression is a debilitating mental disease, characterized by persistent low mood and
anhedonia. Stress represents a major environmental risk factor for depression; the complex …

Background Evidence continues to build suggesting that the GABAergic neurotransmitter
system is altered in brains of patients with major depressive disorder. However, there is little …

Adaptations at the cellular and molecular levels in response to stress and antidepressant
treatment could represent a form of neural plasticity that contributes to the pathophysiology …

Stress facilitates the development of psychiatric disorders in vulnerable individuals. It affects
physiological functions of hippocampal excitatory neurons, but little is known about the …