Translation regulation largely occurs during initiation, which features ribosome assembly
onto mRNAs and selection of the translation start site. Short, upstream ORFs (uORFs) …

Stress-induced eukaryotic translation initiation factor 2 (eIF2) α phosphorylation
paradoxically increases translation of the metazoan activating transcription factor 4 (ATF4) …

Upon exposure to environmental stress, phosphorylation of the α subunit of eIF2 (eIF2α-P)
represses global protein synthesis, coincident with preferential translation of gene …

In the integrated stress response, phosphorylation of eIF2α (eIF2α-P) reduces protein
synthesis to conserve resources and facilitate preferential translation of transcripts that …

Significance: Organisms adapt to changing environments by engaging cellular stress
response pathways that serve to restore proteostasis and enhance survival. A primary …

In response to different environmental stresses, phosphorylation of eukaryotic initiation
factor-2 (eIF2) rapidly reduces protein synthesis, which lowers energy expenditure and …

Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions.
This can be achieved by the phosphorylation-mediated inactivation of a key translation …

During cellular stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) elicits gene
expression designed to ameliorate the underlying cellular disturbance. Central to this stress …

A central mechanism regulating translation initiation in response to environmental stress
involves phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) …

INTRODUCTION Protein synthesis is controlled by a plethora of developmental and
environmental conditions. One intracellular signaling network, the integrated stress …