Upon exposure to environmental stress, phosphorylation of the α subunit of eIF2 (eIF2α-P) represses global protein synthesis, coincident with preferential translation of gene …
In the integrated stress response, phosphorylation of eIF2α (eIF2α-P) reduces protein synthesis to conserve resources and facilitate preferential translation of transcripts that …
Significance: Organisms adapt to changing environments by engaging cellular stress response pathways that serve to restore proteostasis and enhance survival. A primary …
LR Palam, TD Baird, RC Wek - Journal of Biological Chemistry, 2011 - ASBMB
In response to different environmental stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) rapidly reduces protein synthesis, which lowers energy expenditure and …
DE Andreev, PBF O'Connor, C Fahey, EM Kenny… - elife, 2015 - elifesciences.org
Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation …
KM Vattem, RC Wek - … of the National Academy of Sciences, 2004 - National Acad Sciences
During cellular stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) elicits gene expression designed to ameliorate the underlying cellular disturbance. Central to this stress …
RC Wek - Cold Spring Harbor perspectives in biology, 2018 - cshperspectives.cshlp.org
A central mechanism regulating translation initiation in response to environmental stress involves phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) …
SR Starck, JC Tsai, K Chen, M Shodiya, L Wang… - Science, 2016 - science.org
INTRODUCTION Protein synthesis is controlled by a plethora of developmental and environmental conditions. One intracellular signaling network, the integrated stress …