Metronomic chemotherapy describes the close, regular administration of chemotherapy
drugs at less-toxic doses over prolonged periods of time. In 2015, the results of randomized …

Tumor angiogenesis is recognized as a major therapeutic target in the fight against cancer.
The key involvement of angiogenesis in tumor growth and metastasis has started to redefine …

Metronomic chemotherapy, continuous and dose‐dense administration of chemotherapeutic
drugs with lowered doses, is being evaluated for substituting, augmenting, or appending …

Purpose Over the past few years, more and more new selective molecules directed against
specific cellular targets have become available for cancer therapy, leading to impressive …

Simple Summary The present article reviews the state of the art of metronomic
chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung …

Metronomic chemotherapy (MC) refers to the close administration of a chemotherapeutic
drug for a long time with no extended drug-free breaks. It was developed to overcome drug …

The administration of chemotherapy at reduced doses given at regular, frequent time
intervals, termed 'metronomic'chemotherapy, presents an alternative to standard maximal …

The introduction of the “maximum tolerated dose” in usual treatment protocols (and its
concomitant overt toxicity) made necessary the imposition of rest periods between cycles of …

Metronomic chemotherapy refers to the close, regular administration of comparatively low
doses of cytotoxic drugs, with minimal or no drug-free breaks, over prolonged periods. It is …

Cancer chemotherapy doses are empirical in that the majority are administered at a fixed
dose (mg/m 2 or mg/kg). One reason for this is the intrinsic sensitivity of the tumour or host …