UV-Assisted hyperbranched poly (β-amino ester) modification of a silica membrane for two-step microfluidic DNA extraction from blood

A Jagannath, Y Li, H Cong, J Hassan… - … Applied Materials & …, 2023 - ACS Publications
Integrating nucleic acid extraction in amplification-based point-of-care diagnostics will be a
significant feature for next-generation point-of-care virus detection devices. However …

Thin film microextraction enables rapid isolation and recovery of DNA for downstream amplification assays

DR Eitzmann, M Varona, JL Anderson - Analytical Chemistry, 2022 - ACS Publications
Nucleic acid analysis has been at the forefront of the COVID-19 global health crisis where
millions of diagnostic tests have been used to determine disease status as well as …

A point-of-care microfluidic biosensing system for rapid and ultrasensitive nucleic acid detection from clinical samples

Y Zhang, Y Song, Z Weng, J Yang, L Avery… - Lab on a Chip, 2023 - pubs.rsc.org
Rapid and ultrasensitive point-of-care RNA detection plays a critical role in the diagnosis
and management of various infectious diseases. The gold-standard detection method of …

Poly-L-histidine coated microfluidic devices for bacterial DNA purification without chaotropic solutions

AS Kastania, PS Petrou, CM Loukas… - Biomedical …, 2020 - Springer
We present a disposable polymeric microfluidic device capable of reversibly binding and
purifying Salmonella DNA through solid phase extraction (SPE). The microfluidic channels …

Multiple on-line active valves based centrifugal microfluidics for dynamic solid-phase enrichment and purification of viral nucleic acid

S Li, C Wan, Y Xiao, C Liu, X Zhao, Y Zhang, H Yuan… - Lab on a Chip, 2024 - pubs.rsc.org
Point of care testing (POCT) of nucleic acids holds significant importance in the realm of
infectious disease prevention and control, as well as the advancement of personalized …

Lentivirus capture directly from cell culture with Q-functionalised microcapillary film chromatography

NJ Darton, D Darling, MJ Townsend, DJ McNally… - … of Chromatography A, 2012 - Elsevier
A new disposable adsorbent material for fast anion-exchange capture of nano-complexes
without prefiltering, clarification or pre-processing of samples was developed based on …

Fully 3D printed integrated reactor array for point-of-care molecular diagnostics

K Kadimisetty, J Song, AM Doto, Y Hwang… - Biosensors and …, 2018 - Elsevier
Molecular diagnostics that involve nucleic acid amplification tests (NAATs) are crucial for
prevention and treatment of infectious diseases. In this study, we developed a simple …

Multiplex detection of blood-borne pathogens on a self-driven microfluidic chip using loop-mediated isothermal amplification

C Xie, S Chen, L Zhang, X He, Y Ma, H Wu… - Analytical and …, 2021 - Springer
Detection of blood-borne pathogens such as hepatitis C virus (HCV), hepatitis B virus (HBV)
and human immunodeficiency virus (HIV) is essential to ensure the safety of blood …

One-step pathogen specific DNA extraction from whole blood on a centrifugal microfluidic device

YK Cho, JG Lee, JM Park, BS Lee, Y Lee, C Ko - Lab on a Chip, 2007 - pubs.rsc.org
We report a fully integrated, pathogen-specific DNA extraction device utilizing centrifugal
microfluidics on a polymer based CD platform. By use of the innovative laser irradiated …

A point of care platform based on microfluidic chip for nucleic acid extraction in less than 1 minute

J Zhang, X Su, J Xu, J Wang, J Zeng, C Li, W Chen… - …, 2019 - pubs.aip.org
In view of the complex procedure of nucleic acid extraction, there exists a huge challenge for
the widespread use of point-of-care diagnostics for nucleic acid testing. To achieve point-of …