Common drugs alter microbial protein expression, but not composition in fecal cultures from Crohn's disease patients

H Becker, R Mohren, G Le, L Derijks, D Jonkers… - bioRxiv, 2023 - biorxiv.org
Introduction: A substantial number of Crohn's disease (CD) patients experience side-effects
and/or non-response to medical drugs. In part, this might be attributed to the interaction of …

DOP08 A novel multiomic approach to unravel the mechanisms of action of biologics and tofacitinib in Inflammatory Bowel Disease

M Baldan-Martin, M Azkargorta… - Journal of Crohn's …, 2024 - academic.oup.com
Background Inflammatory bowel diseases (IBD), which includes Crohn´ s disease (CD) and
ulcerative colitis (UC), are complex and heterogeneous diseases characterized by a …

Current evidence and clinical relevance of drug-microbiota interactions in inflammatory bowel disease

HEF Becker, K Demers, LJJ Derijks… - Frontiers in …, 2023 - frontiersin.org
Background Inflammatory bowel disease (IBD) is a chronic relapsing-remitting disease. An
adverse immune reaction toward the intestinal microbiota is involved in the pathophysiology …

Anti-inflammatory gut microbial pathways are decreased during Crohn's disease exacerbations

MAY Klaassen, F Imhann, V Collij, J Fu… - Journal of Crohn's …, 2019 - academic.oup.com
Abstract Background and Aims Crohn's disease [CD] is a chronic inflammatory disorder of
the gastrointestinal tract characterised by alternating periods of exacerbation and remission …

Fecal microbiota alterations associated with clinical and endoscopic response to infliximab therapy in Crohn's disease

X Zhuang, Z Tian, R Feng, M Li, T Li… - Inflammatory Bowel …, 2020 - academic.oup.com
Background Gut microbiota dysbiosis is associated with the occurrence and development of
Crohn disease (CD). Currently, infliximab (IFX) is used more and more to treat CD; however …

Interactions between medications and the gut microbiome in inflammatory bowel disease

J Eckenberger, JC Butler, CN Bernstein, F Shanahan… - Microorganisms, 2022 - mdpi.com
In view of the increasing evidence that commonly prescribed, non-antibiotic drugs interact
with the gut microbiome, we re-examined the microbiota variance in inflammatory bowel …

[PDF][PDF] Microbiota and drug response in inflammatory bowel disease. Pathogens 2021; 10: 211

M Franzin, K Stefancic, M Lucafò, G Decorti, G Stocco - 2021 - academia.edu
A mutualistic relationship between the composition, function and activity of the gut
microbiota (GM) and the host exists, and the alteration of GM, sometimes referred as …

P334 The longitudinal analysis of fecal microbiota in response to ustekinumab treatment in patients with Crohn's disease

J Kim, MK Kim, AR Yoon, SW Hong… - Journal of Crohn's …, 2024 - academic.oup.com
Background Emerging evidence supports that treatment of Crohn's disease (CD) can alter
the intestinal microbiota, which can play a significant role in the pathogenesis and …

P852 Metataxonomic and metabolomic profiling to predict response to anti-TNF therapy in Crohn's Disease

J Foyzul, JL Alexander, KE Chappell… - Journal of Crohn's …, 2024 - academic.oup.com
Background The composition of the gut microbiota is associated with response to treatments
in inflammatory bowel disease1. We sought to identify gut microbial and metabolomic …

Deciphering Microbial Composition in Patients with Inflammatory Bowel Disease: Implications for Therapeutic Response to Biologic Agents

O Palmieri, F Bossa, S Castellana, T Latiano… - Microorganisms, 2024 - mdpi.com
Growing evidence suggests that alterations in the gut microbiome impact the development of
inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis …