Hypoxia is one of the prominent features of solid tumors. Hypoxia activated prodrugs
(HAPs), selectively killing hypoxic cells, possess the potential to transform hypoxia from a …

Hypoxia is a feature of solid tumors that greatly hinders cancer treatment. Here, we
developed hypoxia-responsive nanoparticles (NPs) that selectively release chlorin e6 (Ce6) …

Tumor hypoxia, which is indispensable to tumor propagation and therapy resistance, has
been one of the most important factors influencing clinical outcomes. To modulate the …

Photodynamic therapy (PDT) can aggravate the hypoxia aggravation and be further utilized
for the activation of hypoxia-activated prodrug (HAP). Ideally, photosensitizers (PSs) are …

Herein, we report a light-enhanced hypoxia-responsive nanoparticle for synergic treatment
of solid tumors. The conversion of oxygen in the tumor exterior induced ROS and the …

Hypoxia is a common feature within many types of solid tumors, which is closely associated
with limited efficacy for tumor therapies. Moreover, the inability to reach hypoxic tumor cells …

Since the hypoxia tumor microenvironment (TME) will not only limit the treatment effect but
also cause tumor recurrence and metastasis, intratumoral aggravated hypoxia level induced …

Phototherapy, including photodynamic therapy and photothermal therapy, mainly relies on
phototherapeutic agents (PAs) to produce heat or toxic reactive oxygen species (ROS) to kill …

With the development of redox-related therapy modalities in cancer therapy, photodynamic
therapy (PDT) has gradually become the most widely used type in the clinic. However, the …

Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the
tumor cells. Oxygen-consumption photodynamic therapy (PDT) suffers from the undesirable …