Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of scale-specific biomolecular data on cancer …

Over the past decade, we have witnessed an increasing number of large-scale studies that
have provided multi-omics data by high-throughput sequencing approaches. This has …

The transformation of normal cells into cancer cells and maintenance of the malignant state
and phenotypes are associated with genetic and epigenetic deregulations, altered cellular …

Recent progress in our understanding of cancer mostly relies on the systematic profiling of
patient samples with high-throughput techniques like transcriptomics. With this approach …

Multi-scale models integrating biomolecular data from genetic, transcriptional, and
translational levels, coupled with extracellular microenvironments can assist in decoding the …

Cancer cells contain numerous mutations in the genome that are present in most or all
malignant cells of a tumor. While not all mutations are significant for cancer progression, a …

It is becoming evident that holistic perspectives toward cancer are crucial in deciphering the
overwhelming complexity of tumors. Single-layer analysis of genome-wide data has greatly …

'The definitive property of individuality at the organismal level lies in the effective
suppression of the differential propagation of subparts as a necessary strategy for …

Despite diagnostic, preventive and therapeutic advances, the growing incidence of cancer
and the high rate of mortality among patients affected by specific cancer types indicate that …

Cancer is a highly complex disease that is often characterized by vast changes in the
genetic and epigenetic landscape. Those changes result in altered protein expression levels …