Bone marrow-derived mesenchymal stromal cell therapy in severe COVID-19: preliminary results of a phase I/II clinical trial

C Grégoire, N Layios, B Lambermont… - Frontiers in …, 2022 - frontiersin.org
Background Treatment of acute respiratory distress syndrome (ARDS) associated with
COronaVIrus Disease-2019 (COVID-19) currently relies on dexamethasone and supportive …

[HTML][HTML] Mesenchymal stromal cells as potential immunomodulatory players in severe acute respiratory distress syndrome induced by SARS-CoV-2 infection

P Mallis, E Michalopoulos… - World Journal of Stem …, 2020 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus-2 and the related coronavirus disease-19
(COVID-19) is a worldwide emerging situation, which was initially reported in December …

Mesenchymal stem cells: a new front emerges in coronavirus disease 2019 treatment

SS Raza, MA Khan - Cytotherapy, 2022 - Elsevier
Currently, treating coronavirus disease 2019 (COVID-19) patients, particularly those afflicted
with severe pneumonia, is challenging, as no effective pharmacotherapy for severe acute …

Mesenchymal stromal cell therapy for COVID-19-induced ARDS patients: a successful phase 1, control-placebo group, clinical trial

N Kaffash Farkhad, A Sedaghat, H Reihani… - Stem Cell Research & …, 2022 - Springer
Background Acute respiratory distress syndrome (ARDS) is the devastating complication of
the new COVID-19 pandemic, directly correlated with releasing large amounts of …

Current status of cell-based therapies for COVID-19: evidence from mesenchymal stromal cells in sepsis and ARDS

Z Xu, Y Huang, J Zhou, X Deng, W He, X Liu… - Frontiers in …, 2021 - frontiersin.org
The severe respiratory consequences of the coronavirus disease 2019 (COVID-19)
pandemic have prompted the urgent need for novel therapies. Cell-based therapies …

Safety and efficacy of mesenchymal stem cells in severe/critical patients with COVID-19: A systematic review and meta-analysis

W Yao, H Dong, J Qi, Y Zhang, L Shi - EClinicalMedicine, 2022 - thelancet.com
Background The present study aims to better understand the efficacy and safety of
mesenchymal stromal cells (MSCs) in treating severe/critical patients with COVID-19 …

Cell-based therapy to reduce mortality from COVID-19: Systematic review and meta-analysis of human studies on acute respiratory distress syndrome

W Qu, Z Wang, JM Hare, G Bu… - Stem Cells …, 2020 - academic.oup.com
Severe cases of COVID-19 infection, often leading to death, have been associated with
variants of acute respiratory distress syndrome (ARDS). Cell therapy with mesenchymal …

Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms

R Zhu, T Yan, Y Feng, Y Liu, H Cao, G Peng, Y Yang… - Cell research, 2021 - nature.com
The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells
(MSCs) potentially improves clinical symptoms, but the underlying mechanism remains …

Human mesenchymal stem cell therapy in severe COVID-19 patients: 2-year follow-up results of a randomized, double-blind, placebo-controlled trial

TT Li, B Zhang, H Fang, M Shi, WQ Yao, Y Li… - …, 2023 - thelancet.com
Background Long-term effects of human mesenchymal stem cell (MSC) treatment on COVID-
19 patients have not been fully characterized. The aim of this study was to evaluate the …

The rationale of using mesenchymal stem cells in patients with COVID-19-related acute respiratory distress syndrome: What to expect

A Can, H Coskun - Stem Cells Translational Medicine, 2020 - academic.oup.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused coronavirus
disease 2019 (COVID-19) pandemic has become a global health crisis with an extremely …