Genotypic analysis of RTS, S/AS01E malaria vaccine efficacy against parasite infection as a function of dosage regimen and baseline malaria infection status in …

M Juraska, AM Early, L Li, SF Schaffner… - The Lancet Infectious …, 2024 - thelancet.com
Background The first licensed malaria vaccine, RTS, S/AS01 E, confers moderate protection
against symptomatic disease. Because many malaria infections are asymptomatic, we …

Efficacy of RTS, S/AS01E malaria vaccine administered according to different full, fractional, and delayed third or early fourth dose regimens in children aged 5–17 …

AM Samuels, D Ansong, SK Kariuki, S Adjei… - The Lancet Infectious …, 2022 - thelancet.com
Background Controlled infection studies in malaria-naive adults suggest increased vaccine
efficacy for fractional-dose versus full-dose regimens of RTS, S/AS01. We report first results …

Seven-year efficacy of RTS, S/AS01 malaria vaccine among young African children

A Olotu, G Fegan, J Wambua… - … England Journal of …, 2016 - Mass Medical Soc
Background The candidate malaria vaccine RTS, S/AS01 is being evaluated in order to
inform a decision regarding its inclusion in routine vaccination schedules. Methods We …

Design of a phase III multicenter trial to evaluate the efficacy of the RTS, S/AS01 malaria vaccine in children across diverse transmission settings in Africa

A Leach, J Vekemans, M Lievens, O Ofori-Anyinam… - Malaria journal, 2011 - Springer
Abstract Background GlaxoSmithKline Biologicals and the PATH Malaria Vaccine Initiative
are working in partnership to develop a malaria vaccine to protect infants and children living …

Efficacy of RTS, S malaria vaccines: individual-participant pooled analysis of phase 2 data

P Bejon, MT White, A Olotu, K Bojang… - The Lancet infectious …, 2013 - thelancet.com
Background The efficacy of RTS, S/AS01 as a vaccine for malaria is being tested in a phase
3 clinical trial. Early results show significant, albeit partial, protection against clinical malaria …

Feasibility, safety, and impact of the RTS, S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised …

KP Asante, DP Mathanga, P Milligan, S Akech, A Oduro… - The Lancet, 2024 - thelancet.com
Summary Background The RTS, S/AS01 E malaria vaccine (RTS, S) was introduced by
national immunisation programmes in Ghana, Kenya, and Malawi in 2019 in large-scale …

Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children

S Owusu-Agyei, D Ansong, K Asante… - PLoS …, 2009 - journals.plos.org
Background The target delivery channel of RTS, S candidate malaria vaccines in malaria-
endemic countries in Africa is the World Health Organisation Expanded Program on …

Efficacy and safety of the RTS, S/AS01 malaria vaccine during 18 months after vaccination: a phase 3 randomized, controlled trial in children and young infants at 11 …

RTS, S Clinical Trials Partnership (2014) - PLoS medicine, 2014 - journals.plos.org
Background A malaria vaccine could be an important addition to current control strategies.
We report the safety and vaccine efficacy (VE) of the RTS, S/AS01 vaccine during 18 mo …

Safety and immunogenicity of the RTS, S/AS02A candidate malaria vaccine in children aged 1–4 in Mozambique

E Macete, JJ Aponte, C Guinovart… - Tropical Medicine & …, 2007 - Wiley Online Library
Background The development of a malaria vaccine remains a public health priority for sub‐
Saharan Africa. RTS, S/AS02A candidate malaria vaccine has been shown to be safe and …

Safety of the Malaria Vaccine Candidate, RTS,S/AS01E in 5 to 17 Month Old Kenyan and Tanzanian Children

J Lusingu, A Olotu, A Leach, M Lievens, J Vekemans… - PLoS …, 2010 - journals.plos.org
The malaria vaccine candidate, RTS, S/AS01E, showed promising protective efficacy in a
trial of Kenyan and Tanzanian children aged 5 to 17 months. Here we report on the …