Abstract Coronavirus disease‐19 (COVID‐19) is caused by severe acute respiratory
syndrome‐coronavirus‐2 (SARS‐CoV‐2) infection. The COVID‐19 pandemic began in …

The coronavirus disease 2019 (COVID-19) pandemics is a challenge without precedent for
the modern science. Acute Respiratory Discomfort Syndrome (ARDS) is the most common …

To discover new drugs to combat COVID-19, an understanding of the molecular basis of
SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of …

The widespread coronavirus SARS-CoV-2 has already infected over 4 million people
worldwide, with a death toll over 280,000. Current treatment of COVID-19 patients relies …

The severity of the SARS-CoV-2 pandemic and the recurring (re) emergence of viruses
prompted the development of new therapeutic approaches that target viral and host factors …

Many studies have shown that the lysosomal cathepsins, especially cathepsins B/L
(CTSB/L) are required for SARS-CoV-2 entry into host cells. Lysosomal proteases …

Emerging RNA viruses, including SARS-CoV-2, continue to be a major threat. Cell entry of
SARS-CoV-2 particles via the endosomal pathway involves cysteine cathepsins. Due to …

Cathepsins (Cats) are proteases that mediate the successful entry of SARS-CoV-2 into host
cells. We designed and synthesized a tailored series of 21 peptidomimetics and evaluated …

The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has
led to substantial mortality, together with mass global disruption. There is an urgent need for …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) seems to employ two
routes of entrance to the host cell; via membrane fusion (with the cells expressing both …