A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts

J Chen, JA Neil, JP Tan, R Rudraraju, M Mohenska… - Nature Cell …, 2023 - nature.com
SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19
during pregnancy to negative birth outcomes and placentitis. However, the …

[HTML][HTML] Human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection

D Ruan, ZW Ye, S Yuan, Z Li, W Zhang, CP Ong… - Cell Reports …, 2022 - cell.com
Direct in vivo investigation of human placenta trophoblast's susceptibility to SARS-CoV-2 is
challenging. Here we report that human trophoblast stem cells (hTSCs) and their derivatives …

Single-cell RNA-seq identifies cell subsets in human placenta that highly expresses factors driving pathogenesis of SARS-CoV-2

N Ashary, A Bhide, P Chakraborty, S Colaco… - Frontiers in cell and …, 2020 - frontiersin.org
Infection by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) results in
the novel coronavirus disease COVID-19, which has posed a serious threat globally …

The effects of COVID-19 on placenta and pregnancy: what do we know so far?

YP Wong, TY Khong, GC Tan - Diagnostics, 2021 - mdpi.com
The current coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has inflicted a serious health crisis …

Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection

L Gao, V Mathur, SKM Tam, X Zhou, MF Cheung… - Nature Cell …, 2023 - nature.com
During pregnancy the maternal–fetal interface plays vital roles in fetal development. Its
disruption is frequently found in pregnancy complications. Recent studies show increased …

SARS-CoV-2 can infect and propagate in human placenta explants

A Fahmi, M Brügger, T Démoulins, B Zumkehr… - Cell Reports …, 2021 - cell.com
The ongoing SARS-CoV-2 pandemic continues to lead to high morbidity and mortality.
During pregnancy, severe maternal and neonatal outcomes and placental pathological …

Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface

A Lu-Culligan, AR Chavan, P Vijayakumar, L Irshaid… - Med, 2021 - cell.com
Background Pregnant women are at increased risk for severe outcomes from coronavirus
disease 2019 (COVID-19), but the pathophysiology underlying this increased morbidity and …

[HTML][HTML] Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy

LB Argueta, LA Lacko, Y Bram, T Tada, L Carrau… - Iscience, 2022 - cell.com
The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis of
placentas from women who tested positive at delivery showed SARS-CoV-2 genomic and …

[HTML][HTML] SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers

JL Hecht, B Quade, V Deshpande, M Mino-Kenudson… - Modern Pathology, 2020 - Elsevier
Congenital infection of SARS-CoV-2 appears to be exceptionally rare despite many cases of
COVID-19 during pregnancy. Robust proof of placental infection requires demonstration of …

Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2

V Garcia-Flores, R Romero, Y Xu, KR Theis… - Nature …, 2022 - nature.com
Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality.
However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and …