Resistance to β-lactam antibiotics in Gram-negatives producing metallo-β-lactamases
(MBLs) represents a major medical threat and there is an extremely urgent need to develop …

Abstract Metallo‐β‐lactamases (MBLs) are increasingly involved as a major mechanism of
resistance to carbapenems in relevant opportunistic Gram‐negative pathogens …

To fight the increasingly worrying bacterial resistance to antibiotics, the discovery and
development of new therapeutics is urgently needed. Here, we report on a new series of 1 …

Abstract Metallo-β-lactamases (MBLs) are important contributors of Gram-negative bacteria
resistance to β-lactam antibiotics. MBLs are highly worrying because of their …

Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to
carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to …

In Gram-negative bacteria, the major mechanism of resistance to β-lactam antibiotics is the
production of one or several β-lactamases (BLs), including the highly worrying …

Abstract Metallo-β-lactamases (MBLs) represent an increasingly serious threat to public
health because of their increased prevalence worldwide in relevant opportunistic Gram …

Bacterial resistance to β-lactam antibiotics caused by class B metallo-β-lactamases (MBL),
especially for certain hospital-acquired, Gram-negative pathogens, poses a significant threat …

Abstract Metallo-β-lactamases (MBLs) are an emerging cause of bacterial antibiotic
resistance by hydrolysing all classes of β-lactams except monobactams, and the MBLs are …

Abstract Metallo‐β‐lactamases (MBLs) cause resistance of Gram‐negative bacteria to β‐
lactam antibiotics and are of serious concern, because they can inactivate the last‐resort …