GLP-1 in the Hypothalamic Paraventricular Nucleus Promotes Sympathetic Activation and Hypertension

XY Xu, JX Wang, JL Chen, M Dai… - Journal of …, 2024 - Soc Neuroscience
Glucagon-like peptide-1 (GLP-1) and its analogs are widely used for diabetes treatment. The
paraventricular nucleus (PVN) is crucial for regulating cardiovascular activity. This study …

Effects of centrally administered glucagon-like peptide-2 on blood pressure and barosensitive neurons in spontaneously hypertensive rats

S Sasaki-Hamada, K Narusawa, R Nakamura… - Neuropeptides, 2018 - Elsevier
The central administration of glucagon-like peptide-2 (GLP-2) decreases blood pressure in
rats. In the present study, we investigated the hypotensive effects of GLP-2 using …

Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans

AE Bharucha, N Charkoudian… - American Journal …, 2008 - journals.physiology.org
Glucagon-like peptide-1 (GLP-1), an incretin, which is used to treat diabetes mellitus in
humans, inhibited vagal activity and activated nitrergic pathways. In rats, GLP-1 also …

PPG neurons of the lower brain stem and their role in brain GLP-1 receptor activation

S Trapp, SC Cork - American Journal of Physiology …, 2015 - journals.physiology.org
Within the brain, glucagon-like peptide-1 (GLP-1) affects central autonomic neurons,
including those controlling the cardiovascular system, thermogenesis, and energy balance …

Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity

C Cabou, G Campistron, N Marsollier, C Leloup… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—To ascertain the importance and mechanisms underlying the role of brain
glucagon-like peptide (GLP)-1 in the control of metabolic and cardiovascular function. GLP-1 …

[HTML][HTML] Central glucagon-like peptide-1 receptor signaling via brainstem catecholamine neurons counteracts hypertension in spontaneously hypertensive rats

K Katsurada, M Nakata, T Saito, B Zhang, Y Maejima… - Scientific reports, 2019 - nature.com
Abstract Glucagon-like peptide-1 receptor (GLP-1R) agonists, widely used to treat type 2
diabetes, reduce blood pressure (BP) in hypertensive patients. Whether this action involves …

[HTML][HTML] GLP-1 mediated diuresis and natriuresis are blunted in heart failure and restored by selective afferent renal denervation

K Katsurada, SS Nandi, H Zheng, X Liu… - Cardiovascular …, 2020 - Springer
Abstract Background Glucagon-like peptide-1 (GLP-1) induces diuresis and natriuresis.
Previously we have shown that GLP-1 activates afferent renal nerve to increase efferent …

[HTML][HTML] Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons

H Yamamoto, CE Lee, JN Marcus… - The Journal of …, 2002 - Am Soc Clin Investig
Glucagon-like peptide-1 (GLP-1) released from the gut functions as an incretin that
stimulates insulin secretion. GLP-1 is also a brain neuropeptide that controls feeding and …

GLP-1 reduces cerebrospinal fluid secretion and intracranial pressure: a novel treatment for idiopathic intracranial hypertension?

H Botfield, M Uldall, J Mitchell… - Endocrine …, 2015 - endocrine-abstracts.org
Background: Idiopathic intracranial hypertension (IIH) predominantly affects obese women
of childbearing age. IIH is characterised by increased intracranial pressure (ICP) which …

[HTML][HTML] The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice

LL Baggio, JR Ussher, BA McLean, X Cao… - Molecular …, 2017 - Elsevier
Abstract Objectives Glucagon-like peptide-1 (GLP-1) is secreted from enteroendocrine cells
and exerts a broad number of metabolic actions through activation of a single GLP-1 …