Brief transient episodes of nonlethal myocardial ischemia protect or “precondition” the heart
and render the myocardium resistant to a subsequent more sustained ischemic insult. The …

Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

Coronary heart disease (CHD) is the leading cause of death world-wide. Its major
pathophysiological manifestation is acute myocardial ischaemia–reperfusion injury …

Despite nearly twenty years of research into the field of ischemic preconditioning, the actual
mechanism of protection remains unclear. However, much progress has been made in …

Preconditioning the myocardium using short episodes of sublethal ischaemia will delay the
onset of necrosis during a subsequent lethal ischaemic insult. This powerful protective …

Ischemic preconditioning describes the increased resistance to myocardial infarction that
follows short sublethal periods of ischemia. After the ischemia that triggers preconditioning …

CORONARY HEART DISEASE is the leading cause of death in the Western world and
represents one of the major burdens on healthcare systems today. Targeting those …

The discovery of preconditioning (PC) has arguably been the single most important
development in the field of ischemic biology in the past 20 years. The significance of this …

Background In the experimental setting, it has been demonstrated that preconditioning
myocardium before prolonged occlusion with brief ischemic episodes affords substantial …

The 30-year anniversary of the discovery of'ischaemic preconditioning'is in 2016. This
endogenous phenomenon can paradoxically protect the heart from acute myocardial …