The flexibility of the epigenome has generated an enticing argument to explore its reversion
through pharmacological treatments as a strategy to ameliorate disease phenotypes. All …

Introduction: Epigenetic modification has been implicated in a wide range of diseases and
the ability to modulate such systems is a lucrative therapeutic strategy in drug discovery …

There are pronounced interindividual variations in drug metabolism, drug responses, and
the incidence of adverse drug reactions. To a certain extent such variability can be …

Epigenetics is a new development in complex non-Mendelian disease, which may not only
uncover etiologic and pathogenic mechanisms but may also provide the basis for the …

Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …

Epigenetics is a molecular phenomenon that pertains to heritable changes in gene
expression that do not involve changes in the DNA sequence. Epigenetic modifications in a …

Epigenetics, heritable changes in gene expression that do not involve changes in DNA
sequence, is known to be involved in disease. Two important epigenetic changes that are …

Introduction: Epigenetics is the study of reversible modifications to chromatin and their
extensive and profound effects on gene regulation. To date, the role of epigenetics in …

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition,
provides a comprehensive analysis of epigenetics, from basic biology, to clinical application …

Background Modulating the epigenome has long been considered a potential opportunity
for therapeutic intervention in numerous disease areas with several approved therapies …