The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study

W Cheng, N Parker, N Karadag, E Koch… - The Lancet …, 2023 - thelancet.com
Background The relationship between psychotic disorders and cannabis use is heavily
debated. Shared underlying genetic risk is one potential explanation. We investigated the …

[HTML][HTML] A large-scale genome-wide association study meta-analysis of cannabis use disorder

EC Johnson, D Demontis, TE Thorgeirsson… - The Lancet …, 2020 - thelancet.com
Background Variation in liability to cannabis use disorder has a strong genetic component
(estimated twin and family heritability about 50–70%) and is associated with negative …

Genetic association between schizophrenia and cannabis use

KJH Verweij, A Abdellaoui, MG Nivard, AS Cort… - Drug and alcohol …, 2017 - Elsevier
Background and aim Previous studies have shown a relationship between schizophrenia
and cannabis use. As both traits are substantially heritable, a shared genetic liability could …

[HTML][HTML] Factors moderating the association between cannabis use and psychosis risk: a systematic review

SJ Van der Steur, A Batalla, MG Bossong - Brain sciences, 2020 - mdpi.com
Increasing evidence indicates a relationship between cannabis use and psychosis risk.
Specific factors, such as determinants of cannabis use or the genetic profile of cannabis …

Psychotic patients who used cannabis frequently before illness onset have higher genetic predisposition to schizophrenia than those who did not

M Aas, I Melle, F Bettella, S Djurovic… - Psychological …, 2018 - cambridge.org
BackgroundSchizophrenia (SZ) and bipolar disorder (BD) are heritable, polygenic disorders
with shared clinical and genetic components, suggesting a psychosis continuum. Cannabis …

Genetic predisposition to schizophrenia associated with increased use of cannabis

RA Power, KJH Verweij, M Zuhair… - Molecular …, 2014 - nature.com
Cannabis is the most commonly used illicit drug worldwide. With debate surrounding the
legalization and control of use, investigating its health risks has become a pressing area of …

[HTML][HTML] Cannabis, schizophrenia genetic risk, and psychotic experiences: a cross-sectional study of 109,308 participants from the UK Biobank

M Wainberg, GR Jacobs, M di Forti… - Translational Psychiatry, 2021 - nature.com
Cannabis is known to produce acute, transient psychotic-like experiences. However, it is
unclear whether cannabis disproportionately increases the risk of specific types of psychotic …

[HTML][HTML] The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond

KJH Verweij, JM Vink, A Abdellaoui… - Translational …, 2022 - nature.com
Cannabis is among the most widely consumed psychoactive substances worldwide.
Individual differences in cannabis use phenotypes can partly be explained by genetic …

Cannabis use, depression and self‐harm: phenotypic and genetic relationships

K Hodgson, JRI Coleman, SP Hagenaars… - …, 2020 - Wiley Online Library
Abstract Background and Aims The use of cannabis has previously been linked to both
depression and self‐harm; however, the role of genetics in this relationship is unclear. This …

The relationship between cannabis and schizophrenia: a genetically informed perspective

EC Johnson, AS Hatoum, JD Deak, R Polimanti… - …, 2021 - Wiley Online Library
Abstract Background and Aims While epidemiological studies support a role for heavy, high‐
potency cannabis use on first‐episode psychosis, genetic models of causation suggest …