Inflammasome: structure, biological functions, and therapeutic targets

Y Dai, J Zhou, C Shi - MedComm, 2023 - Wiley Online Library
Inflammasomes are a group of protein complex located in cytoplasm and assemble in
response to a wide variety of pathogen‐associated molecule patterns, damage‐associated …

Advances in inflammasome research: recent breakthroughs and future hurdles

RE Tweedell, TD Kanneganti - Trends in molecular medicine, 2020 - cell.com
Inflammasomes are a group of cytosolic multiprotein complexes that are assembled in
response to pathogen-and damage-associated molecular patterns and cellular stress …

A 360 view of the inflammasome: Mechanisms of activation, cell death, and diseases

KC Barnett, S Li, K Liang, JPY Ting - Cell, 2023 - cell.com
Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Mechanistic insights from inflammasome structures

J Fu, K Schroder, H Wu - Nature Reviews Immunology, 2024 - nature.com
Inflammasomes are supramolecular complexes that form in the cytosol in response to
pathogen-associated and damage-associated stimuli, as well as other danger signals that …

[HTML][HTML] Structure, activation and regulation of NLRP3 and AIM2 inflammasomes

M Sharma, E de Alba - International Journal of Molecular Sciences, 2021 - mdpi.com
The inflammasome is a three-component (sensor, adaptor, and effector) filamentous
signaling platform that shields from multiple pathogenic infections by stimulating the …

[HTML][HTML] The role of inflammasomes in human diseases and their potential as therapeutic targets

J Yao, K Sterling, Z Wang, Y Zhang… - Signal Transduction and …, 2024 - nature.com
Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

[HTML][HTML] Inflammasome activation and regulation: toward a better understanding of complex mechanisms

D Zheng, T Liwinski, E Elinav - Cell discovery, 2020 - nature.com
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Inflammasomes: mechanism of action, role in disease, and therapeutics

H Guo, JB Callaway, JPY Ting - Nature medicine, 2015 - nature.com
The inflammasomes are innate immune system receptors and sensors that regulate the
activation of caspase-1 and induce inflammation in response to infectious microbes and …

Regulation of inflammasome activation

SM Man, TD Kanneganti - Immunological reviews, 2015 - Wiley Online Library
Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Mechanisms governing inflammasome activation, assembly and pyroptosis induction

S Kesavardhana, TD Kanneganti - International Immunology, 2017 - academic.oup.com
Inflammasomes are multimeric protein complexes that regulate inflammatory responses and
pyroptotic cell death to exert host defense against microbes. Intracellular pattern-recognition …