Regulation of small RNA stability: methylation and beyond
As central components of RNA silencing, small RNAs play diverse and important roles in
many biological processes in eukaryotes. Aberrant reduction or elevation in the levels of …
many biological processes in eukaryotes. Aberrant reduction or elevation in the levels of …
[HTML][HTML] The Arabidopsis nucleotidyl transferase HESO1 uridylates unmethylated small RNAs to trigger their degradation
Y Zhao, Y Yu, J Zhai, V Ramachandran, TT Dinh… - Current Biology, 2012 - cell.com
MicroRNAs (miRNAs), small interfering RNAs (siRNAs), and piwi-interacting RNAs (piRNAs)
impact numerous biological processes in eukaryotes. In addition to biogenesis, turnover …
impact numerous biological processes in eukaryotes. In addition to biogenesis, turnover …
[HTML][HTML] Dynamic RNA modifications in posttranscriptional regulation
Cellular RNAs can be chemically modified over a hundred different ways. These
modifications were once thought to be static, discrete, and utilized to fine-tune RNA structure …
modifications were once thought to be static, discrete, and utilized to fine-tune RNA structure …
The Caenorhabditis elegans HEN1 Ortholog, HENN-1, Methylates and Stabilizes Select Subclasses of Germline Small RNAs
Small RNAs regulate diverse biological processes by directing effector proteins called
Argonautes to silence complementary mRNAs. Maturation of some classes of small RNAs …
Argonautes to silence complementary mRNAs. Maturation of some classes of small RNAs …
[HTML][HTML] The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC
Small silencing RNAs repress gene expression by a set of related mechanisms collectively
called RNA-silencing pathways [1, 2]. In the RNA interference (RNAi) pathway [3], small …
called RNA-silencing pathways [1, 2]. In the RNA interference (RNAi) pathway [3], small …
The emerging role of RNA modifications in the regulation of mRNA stability
SH Boo, YK Kim - Experimental & molecular medicine, 2020 - nature.com
Many studies have highlighted the importance of the tight regulation of mRNA stability in the
control of gene expression. mRNA stability largely depends on the mRNA nucleotide …
control of gene expression. mRNA stability largely depends on the mRNA nucleotide …
Sequence-specific inhibition of small RNA function
Hundreds of microRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) have
been identified from both plants and animals, yet little is known about their biochemical …
been identified from both plants and animals, yet little is known about their biochemical …
Methylation as a crucial step in plant microRNA biogenesis
B Yu, Z Yang, J Li, S Minakhina, M Yang, RW Padgett… - Science, 2005 - science.org
Methylation on the base or the ribose is prevalent in eukaryotic ribosomal RNAs (rRNAs)
and is thought to be crucial for ribosome biogenesis and function. Artificially introduced 2 …
and is thought to be crucial for ribosome biogenesis and function. Artificially introduced 2 …
Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers
Cellular RNAs are naturally decorated with a variety of chemical modifications. The
structural diversity of the modified nucleosides provides regulatory potential to sort groups of …
structural diversity of the modified nucleosides provides regulatory potential to sort groups of …
[HTML][HTML] Dogma derailed: the many influences of RNA on the genome
Epigenetic control of gene expression is a critical component of transcriptional regulation.
Remarkably, the deposition of epigenetic modifications is often guided by noncoding RNAs …
Remarkably, the deposition of epigenetic modifications is often guided by noncoding RNAs …