Advances in therapeutic applications of extracellular vesicles

OPB Wiklander, MÁ Brennan, J Lötvall… - Science translational …, 2019 - science.org
Extracellular vesicles (EVs) are nanometer-sized, lipid membrane–enclosed vesicles
secreted by most, if not all, cells and contain lipids, proteins, and various nucleic acid …

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Therapeutic applications of extracellular vesicles: clinical promise and open questions

B György, ME Hung, XO Breakefield… - Annual review of …, 2015 - annualreviews.org
This review provides an updated perspective on rapidly proliferating efforts to harness
extracellular vesicles (EVs) for therapeutic applications. We summarize current knowledge …

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

DE Murphy, OG de Jong, M Brouwer… - … & molecular medicine, 2019 - nature.com
Extracellular vesicles (EVs) are increasingly being recognized as mediators of intercellular
signaling via the delivery of effector molecules. Interestingly, certain types of EVs are also …

Stem cell extracellular vesicles: extended messages of regeneration

M Riazifar, EJ Pone, J Lötvall… - Annual review of …, 2017 - annualreviews.org
Stem cells are critical to maintaining steady-state organ homeostasis and regenerating
injured tissues. Recent intriguing reports implicate extracellular vesicles (EVs) as carriers for …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

Extracellular vesicles: opportunities and challenges for the treatment of renal diseases

TT Tang, LL Lv, HY Lan, BC Liu - Frontiers in physiology, 2019 - frontiersin.org
Extracellular vesicles (EVs) are lipid-based membrane-bound particles secreted by virtually
all types of cells under both physiological and pathological conditions. Given their unique …

[HTML][HTML] Extracellular vesicles: emerging tools as therapeutic agent carriers

S Liu, X Wu, S Chandra, C Lyon, B Ning, J Fan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …

Re-engineering extracellular vesicles as smart nanoscale therapeutics

JPK Armstrong, MN Holme, MM Stevens - ACS nano, 2017 - ACS Publications
In the past decade, extracellular vesicles (EVs) have emerged as a key cell-free strategy for
the treatment of a range of pathologies, including cancer, myocardial infarction, and …

Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine

TN Lamichhane, S Sokic, JS Schardt… - … Engineering Part B …, 2015 - liebertpub.com
Extracellular vesicles (EVs)—comprising a heterogeneous population of cell-derived lipid
vesicles including exosomes, microvesicles, and others—have recently emerged as both …