Based on medicinal chemistry tools, new compounds for malaria treatment were designed.
The scaffolds of the drugs used to treat malaria, such as chloroquine, primaquine …

Malaria remains one of the most serious global infectious diseases. An important target for
antimalarial chemotherapy is the enzyme dihydroorotate dehydrogenase from Plasmodium …

The parasitic disease malaria places almost half of the world's population at risk of infection
and is responsible for more than 400,000 deaths each year. The first-line treatment …

Malaria is one of the most prevalent parasitic diseases in the world. The global importance
of this disease, current vector control limitations, and the absence of an effective vaccine …

Malaria remains a major public health problem worldwide, and it is responsible for high
rates of morbidity and mortality. Resistance to current antimalarial drugs has been identified …

Despite recent progress in the fight against malaria, the emergence and spread of drug-
resistant parasites remains a serious obstacle to the treatment of infections. We recently …

To develop new classes of antimalarial agents, the possibility of replacing the phenolic ring
of amodiaquine, tebuquine, and isoquine with other aromatic nuclei was investigated. Within …

In spite of recent efforts to eradicate malaria in the world, this parasitic disease is still
considered a major public health problem, with a total of 216 million cases of malaria and …

This is a general review of currently available antimalarial drugs, these compounds are
gathered according with its chemical structure and the biological targets. A great number of …

In this work, we designed and synthesized 35 new triazolopyrimidine, pyrazolopyrimidine
and quinoline derivatives as P. falciparum inhibitors (3D7 strain). Thirty compounds …