Since the first discovery of an inverse correlation between high‐density lipoprotein‐
cholesterol (HDL‐C) levels and coronary heart disease in the 1950s the life cycle of HDL, its …

Reduced plasma levels of HDL-C are associated with an increased risk of CAD and
myocardial infarction, as shown in various prospective population studies. However, recent …

Evidence that low-density lipoprotein-cholesterol (LDL-C) causes cardiovascular disease
(CVD) is overwhelming. It has also been proven beyond all doubt that lowering the level of …

Background While several lines of evidence prove that elevated concentrations of low-
density lipoproteins (LDL) causally contribute to the development of atherosclerosis and its …

Population studies have shown that plasma HDL levels correlate inversely with
cardiovascular disease risk. In recent years there has been intense interest in developing …

Our understanding of the relationship between the atheroprotective activities of HDL and
heterogeneity of HDL particles has advanced greatly. HDL particles are highly …

Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …

Low plasma levels of HDL-cholesterol (HDL-C) represent a strong and independent risk
factor for cardiovascular disease. HDL particles display a wide spectrum of atheroprotective …

A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for
cardiovascular disease. Epidemiological and clinical studies provide evidence that HDL-C …

Innovative pharmacological approaches to raise anti-atherogenic high-density lipoprotein-
cholesterol (HDL-C) are currently of considerable interest, particularly in atherogenic …