Reproducible brain-wide association studies require thousands of individuals
Magnetic resonance imaging (MRI) has transformed our understanding of the human brain
through well-replicated mapping of abilities to specific structures (for example, lesion …
through well-replicated mapping of abilities to specific structures (for example, lesion …
Multivariate BWAS can be replicable with moderate sample sizes
Brain-wide association studies (BWAS)—which correlate individual differences in
phenotypic traits with measures of brain structure and function—have become a dominant …
phenotypic traits with measures of brain structure and function—have become a dominant …
Towards reproducible brain-wide association studies
Magnetic resonance imaging (MRI) continues to drive many important neuroscientific
advances. However, progress in uncovering reproducible associations between individual …
advances. However, progress in uncovering reproducible associations between individual …
How to establish robust brain–behavior relationships without thousands of individuals
MD Rosenberg, ES Finn - Nature Neuroscience, 2022 - nature.com
Can studying individual differences in brain structure and function reveal individual
differences in behavior? Analyses of MRI data from nearly 50,000 individuals may suggest …
differences in behavior? Analyses of MRI data from nearly 50,000 individuals may suggest …
Replicable brain–phenotype associations require large-scale neuroimaging data
Numerous neuroimaging studies have investigated the neural basis of interindividual
differences but the replicability of brain–phenotype associations remains largely unknown …
differences but the replicability of brain–phenotype associations remains largely unknown …
[HTML][HTML] Ten simple rules for predictive modeling of individual differences in neuroimaging
Establishing brain-behavior associations that map brain organization to phenotypic
measures and generalize to novel individuals remains a challenge in neuroimaging …
measures and generalize to novel individuals remains a challenge in neuroimaging …
Suboptimal phenotypic reliability impedes reproducible human neuroscience
Paragraph Biomarkers of behavior and psychiatric illness for cognitive and clinical
neuroscience remain out of reach–. Suboptimal reliability of biological measurements, such …
neuroscience remain out of reach–. Suboptimal reliability of biological measurements, such …
Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders
Observational studies have reported the correlations between brain imaging-derived
phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal …
phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal …
Linking interindividual variability in brain structure to behaviour
What are the brain structural correlates of interindividual differences in behaviour? More
than a decade ago, advances in structural MRI opened promising new avenues to address …
than a decade ago, advances in structural MRI opened promising new avenues to address …
The burden of reliability: How measurement noise limits brain-behaviour predictions
Current major efforts in human neuroimaging research aim to understand individual
differences and identify biomarkers for clinical applications. One particularly promising …
differences and identify biomarkers for clinical applications. One particularly promising …